Trans 010 Pharma Part 2 Flashcards
Vasodilator for hypertension
a. Prorenin inhibitor
A small molecule and a direct inhibitor of renin
Administered orally and is eliminated mostly unchanged in the urine
Renin inhibitor
The first and only sulfur-containing ACE inhibitor
Captopril
A prodrug that is de-esterified in the
liver to produce enalaprilat, which inhibits ACE
Enalapril
Treatment of hypervolemic
hyponatremia and syndrome of inappropriate
ADH
Conivaptan
Antagonizes both endothelin A and B receptors and reduces pulmonary hypertension
Also for systemic hypertension
Bosentan
are competitive inhibitors at the H1-receptor. These are lipid soluble, readily cross the blood– brain barrier, and have significant CNS actions mediated in large part by their anti-cholinergic activity.
H1 ANTAGONIST (ANTI-H1)
prevents nausea and vomiting before
surgery. Commonly used by anaesthesiologists..
Promethazine
Most common side-effect of the 1st generation drugs is; anti histamine
drowsiness
Drug of choice for Meniere’s syndrome (vertigo) Serc / Merislon –(brandnames)
Betahistine
Used as an appetite suppressant
(anorexigenic) but was withdrawn because of cardiac valve toxicity (pulmonary HPN)
Fibromyalgia another adverse effect
Dexfenfluramine
For ADHD in children, also a reducing pill and
narcolepsy (excessive sleeping) Can increase catecholamine, serotonin, and
glutamate release, and decrease GABA release in various brain regions
Modafinil
Treatment for serotonin syndrome
Brand name: Periactin
Cyproheptadine
The most common precursor of the
eicosanoids
Arachidonic acid
Adverse effect (beneficial) lengthening/growth eyelashes
Bimatoprost
Dextromethorphan versus Butamirate Citrate
Dextromethorphan – central – acting
CI: Bronchial asthma
• Butamirate Citrate (Sinecod Forte) – peripheral acting