Trans 010 Pharma Part 2

Question 1

Vasodilator for hypertension
a. Prorenin inhibitor
 A small molecule and a direct inhibitor of renin
 Administered orally and is eliminated mostly unchanged in the urine

Answer 1

Renin inhibitor

Question 2

The first and only sulfur-containing ACE inhibitor

Answer 2

Captopril

Question 3

A prodrug that is de-esterified in the

liver to produce enalaprilat, which inhibits ACE

Answer 3

Enalapril

Question 4

Treatment of hypervolemic
hyponatremia and syndrome of inappropriate
ADH

Answer 4

Conivaptan

Question 5

Antagonizes both endothelin A and B receptors and reduces pulmonary hypertension
 Also for systemic hypertension

Answer 5

Bosentan

Question 6

are competitive inhibitors at the H1-receptor. These are lipid soluble, readily cross the blood– brain barrier, and have significant CNS actions mediated in large part by their anti-cholinergic activity.

Answer 6

H1 ANTAGONIST (ANTI-H1)

Question 7

prevents nausea and vomiting before

surgery. Commonly used by anaesthesiologists..

Answer 7

Promethazine

Question 8

Most common side-effect of the 1st generation drugs is; anti histamine

Answer 8

drowsiness

Question 9

Drug of choice for Meniere’s syndrome (vertigo)  Serc / Merislon –(brandnames)

Answer 9

Betahistine

Question 10

Used as an appetite suppressant
(anorexigenic) but was withdrawn because of cardiac valve toxicity (pulmonary HPN)
 Fibromyalgia another adverse effect

Answer 10

Dexfenfluramine

Question 11

For ADHD in children, also a reducing pill and
narcolepsy (excessive sleeping) Can increase catecholamine, serotonin, and
glutamate release, and decrease GABA release in various brain regions

Answer 11

Modafinil

Question 12

Treatment for serotonin syndrome

 Brand name: Periactin

Answer 12

Cyproheptadine

Question 13

The most common precursor of the

eicosanoids

Answer 13

Arachidonic acid

Question 14

Adverse effect (beneficial) lengthening/growth
eyelashes

Answer 14

Bimatoprost

Question 15

Dextromethorphan versus Butamirate Citrate

Answer 15

Dextromethorphan – central – acting
 CI: Bronchial asthma
• Butamirate Citrate (Sinecod Forte) – peripheral acting

Question 16

Bromhexine/Ambroxol/Carbocysteine what drag class

Answer 16

mucolytic

Question 17

Guaifenasin drug class

Answer 17

Expectorant

Question 18

A mucolytic that is an antidote for poisoning, antidote for

paracetamol overdose, overdose of cyclophosphamide and watussi poisoning

Answer 18

Acetylcysteine (Poisoning)

Question 19

Safest ANALGESIC – ANTIPYRETIC

Answer 19

Paracetamol

Question 20

Aspirin is contraindicated in children because it produce

Answer 20

Reye syndrome

Question 21

Is due to anesthetic, N20,
succinylcholine – it is a dominant chromosomal abnormality in the skeletal muscle. There is an excitation in the skeletal muscle leading to contraction and hyperthermia, very high fever

Answer 21

. Malignant hyperthermia

Question 22

Treatment for

Malignant hyperthermia

Answer 22

Dantrolene

Question 23

Anti Ace reversible. For the treatment of Myasthei Gravis – disease of the skeletal muscle that affects your NMJ.

Answer 23

Carbamate

Question 24

Drug of choice for

My asthenia? For diaquosis?

Answer 24

Neostigmine is the drug of choice, edrophonium for diagnosis known as tensilon

Question 25

For cigarette smoking sensation

Answer 25

Varenicline

Question 26

The antidote for organophosphate poisioning is cholinergic

Answer 26

Atropine

Question 27

is now used for asthma, antispasmodic, is available as glycopironium bromide for treatment of emphysema.

Answer 27

Glycopyrolate

Question 28

are used for retinal exam – to prevent synechiae after surgery. Used in ophthalmology for diagnosis in the diseases of the eyes, uveitis. Infection of the choroid, iris, and ciliary body.

Answer 28

Cyclopentolate and Tropicamide

Question 29

Shortest? Shorter acting? Long acting? Na mydriatic cyclopegic

Answer 29

The shortest acting is tropicamide, shorter acting is cyclopentolate, the long acting is homatropine, once a day, good for 24 hrs. Atropine is also 24 hours.

Question 30

is a nasal decongestant; pelvic decongestant for priapism; a drug used to localize the lesion of horner’s syndrome. Horner syndrome is due to the obstruction of the sympathetic pathway

Answer 30

Phenylephrine

Question 31

present in neozep, decolgen, causes stroke in US, in the Ph, coronary heart attack

Answer 31

Phenylpropanolamine

Question 32

treatment for orthostatic hypotension

Answer 32

Midodraine

Question 33

for htn,for post menopausal syndrome, diabetic neuropathy and for cigarette smoking sensation din pero di siya drug of choice for

Answer 33

Clonidine

Question 34

the drug of choice for neurogenic hypotension

Answer 34

Droxidopa

Question 35

Pwede sa asthma, pwede sa glaucoma-

Answer 35

Epinephrine

Question 36

Inhibits your phosphodiesterase 5 then increase your CGMP. For male erectile dysfunction

Answer 36

Sildenafil

Question 37

lahat ng to for glaucoma topical drug. Remember these 5

Answer 37

Metipranolol / Betaxolol Timolol / Carteolol / Levobunolol