Train revision

Question 1

MODY inheritence

Answer 1

Autosomal dominant

Question 2

Becker inheritence

Answer 2

X-linked recessive

Question 3

Most common form of MODY?

Answer 3

HNF1 alpha

Question 4

HNF1 MODY?

Answer 4

Most common form, lowers the amount of insulin made by the pacnreas

Question 5

Onset, treatment and complications of glucokinase MODY?

Answer 5

Onset at birth
Stable hyperglycaemia
Diet treatment
Complications rare

Question 6

Onset, treatment and complications of transcription factor mutation MODY? (e.g. HNF1 alpha)

Answer 6

Adolescence/young adult onset
Progressive hyperglycaemia1/3 diet, 1/3 OHA, 1/3 Insulin
Complications frequent

Question 7

Treatment proven to work really well in HNF1 alpha MODY?

Answer 7

Gliclazide

Question 8

Treatment for neontatal diabetes?

Answer 8

Requires insulin treatment within first 3 months of life

remember you have transient and permanent neonatal diabetes though

Question 9

Transient neonatal diabetes

Answer 9

Diabetes usually diagnosed < 1 week
Resolves median 12 weeks
Stop insulin

Question 10

Permanent neonatal diabetes

Answer 10

Diabetes usually diagnosed 0 - 6 weeks

Lifelong treatment with insulin

Question 11

This type of drug binds to the KATP channel in the pancreatic beta cell?

Answer 11

Sulphonylurea

stops hyperpolarisation = cell becomes depolarised = calcium enters = insulin released

Question 12

Mutations in Kir6.2 associated with what?

Answer 12

Associated with PNDM (permanent neonatal diabetes)

Question 13

Neonatal diabetes can be caused by mutations in which channel?

Answer 13

Potassium channel mutations