Toxokinetics and Dynamics

Question 2

Name and describe the 5 mechanisms of death in poisoning.

Answer 2

1. CNS Depression: usually results in respiratory arrest.2. Cardiovascular collapse due to: hypovolemia, hypotension, arrhythmia, hypo/hyperthermia3. Cellular Hypoxia: cyanide poisoning4. Seizures: cocaine and amphetamines cause hyperthermia5. Other: ex. PCP causes hallucinations and patients hurt themselves

Question 3

Name 3 poisons that can lead to an increased anion gap.

Answer 3

1. Methanol2. Ethylene Glycol3. Isoniazid

Question 4

Main drugs that can lead to a hypokalemia.

Answer 4

Thiazide and Loop diuretics

Question 5

Common renal manifestation with ethylene glycol poisoning.

Answer 5

Oxalate crystals in kidneys

Question 6

Drugs that can cause increase QRS or QT interval on EKG.

Answer 6

ORS: TCAs or quinidineQT: lithium or arsenic

Question 7

How does gastric lavage work?

Answer 7

NG tube is placed and saline flushes and washes the stomach and the contents are vacuumed out with suction.