Toxidromes

Question 1

General prevention for nephrotoxins

Answer 1

HYDRATION is the key to kidney protection

Nephrotoxins: aminoglycosides, Amp B, Cisplatin, radio-iodinated contrast media

Question 2

Acetaminophen toxicity

Answer 2

Day 1: n/v, malaise, diaphoresis
Day 2-3: RUQ tenderness, oliguria, pancreatitis, increased ALT/AST PT BUN Scr and bilirubin
Day 3-5: day 1 sx reappear, jaundice, hypoglycemia, bleeding, renal failure, encephalopathy, hepatic necrosis, renal tubular necrosis , protenuria, death
Day 5-14: complete recovery if survived

Question 3

Mineralocorticoids

Answer 3

Decrease K in kidneys

Question 4

Aspirin overdose

Answer 4

Tinnitus
Resp alkalosis from inc resp
Metabolic acidosis due to anaerobic metabolism
Hyperventilation, cold, metabolic acidosis

Question 5

Antimuscarinics and alpha 1 Agonists

Answer 5

Alpha 1 Agonists cause only mydriasis

Antimuscarinics cause mydriasis AND the five old aunties

Question 6

Diltiazem

Answer 6

Will decrease HR and reduce BP