Introduction

Question 1

Vasopressin Antagonists

Answer 1

Conivaptan: high affinity for V1a and V2
Tolvaptan: V2 > V1, risk of hepatotoxicity and liver failure
Antagonism of V2 promotes excretion of free water without electrolytes

Question 2

Mineralocorticoids

Answer 2

Aldosterone
Glomerulosa layer
Fludrocortisone has both mineralocorticoid and glucocorticoid activity
Promotes inc reabsorption of Na and loss of K from DCT

Question 3

HMG-CoA reductase inhibitors

Answer 3

-statins

Rate limiting enzyme in cholesterol syn

Question 4

Bile acid seauestrants

Answer 4

Cholestyramine, Colestipol, Colesevelam

Forms a nonabsorbable complex with bile acids in the intestine

Question 5

Fabric acid derivatives

Answer 5

Fenofibrate, Gemfibrozil

Fenofibric acid: PPAR-alpha agonist, upregulates fa transport and lipoprotein lipase

Question 6

Ezetimibe

Answer 6

Inhinibits absorption of cholesterol at brush border of SI via sterol transporter

Question 7

Insulin

Answer 7

Glucocorticoids dec affinity of insulin receptors for insulin