» The People Need Hard Candies« 1. Tacrolimus 2. Protease inhibitors 3. Niacin 4. HCTZ 5. Corticosteroids

1. Sm cell lung ca 2. Carbamazepine 3. SSRIs 4. Cyclophosphamide

» HAVAc « 1. Halothane 2. Amanita mushroom 3. Valproic acid 4. Acetaminophen

» PS RIF « 1. Pyrizinamide 2. Statins 3. Rifampin 4. Isoniazid 5. Fibrates

» Drugs Causing Sick, Voilent And Nasty Abd Distress « 1. Didanosine 2. Corticosteroids 3. SULFASALAZINE 4. Alcohol 5. Niacin 6. Valproic acid 7. Azathioprine 8. Diuretics

» BNP TF « 1. Bisphosphonates 2. NSAIDs 3. Potassium chloride 4. Tetracycline 5. Ferrous sulphate

» Drugs Can Cause Petty Major Collapse of Granulocytes « 1. Dapsone 2. Carbamazepine 3. Colchicine 4. PTU 5. Methimazole 6. Clozapine 7. Ganciclovir

» Can’t Make New Blood Cells Properly « 1. Carbamazepine 2. Methimazole 3. NSAIDs 4. Benzene 5. Chloramphenicol 5. PTU

» Lupus Makes My HIPS Extremely Painful « 1. Methyldopa 2. Minocycline 3. Hydralazine 4. Isoniazid 5. Phenytoin 6. Sulfa drugs 7. Etanacerpt 6. Procainamide

» hemolysis IS D PAIN « 1. Isoniazid 2. Sulfonamides 3. Dapsone 4. Primaquine 5. Aspirin 6. Ibuprofen 7. Nitrofurantoin

» SAT for a Foto« 1. Sulfonamides 2. Amiodarone 3. Tetracycline 4. 5-FU

» CLAPS « 1. Lamotrigine 2. Allopurinol 3. Penicillin 4. Sulfa drugs 5. Carbamazepine

» BITE « 1. Bupropion 2. Isoniazid. Imipenem 3. Tramadol 4. Enflurane

» Sorry Pals, Can’t Go Mingle « 1. Sulfonylureas 2. Procarbazine 3. Cephalosporin, Chloramphenicol 4. Griseofulvin 5. Metronidazole

Toxicology Flashcards by sputnik s

Abx used for Lead + Copper tox

Penicillinamine, Trientine

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DI Torsades de pointes

Aka Polymorphic VTach

» ABCDEF « 
antiArrhythmics (IA, III) + ARSENIC
antiBiotics (Macrolides+ Fluroquinolones)
antiCychotics
antiDepressants (TCA)
antiEmetics (Odansetron)
Fluconazole

— Amiodarone: least risk of QT prolongation d/t homogeneous effect on ventricular repolarization

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DI Hyperglycemia

» The People Need Hard Candies«

Tacrolimus
Protease inhibitors
Niacin
HCTZ
Corticosteroids

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Which drug causes both Hypo + Hyperthyroidism?

Amiodarone

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DI SIADH

Sm cell lung ca
Carbamazepine
SSRIs
Cyclophosphamide

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DI Hepatic necrosis

» HAVAc «

Halothane
Amanita mushroom
Valproic acid
Acetaminophen

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DI Hepatitis

» PS RIF «

Pyrizinamide
Statins
Rifampin
Isoniazid
Fibrates

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DI pancreatitis

» Drugs Causing Sick, Voilent And Nasty Abd Distress «

Didanosine
Corticosteroids
SULFASALAZINE
Alcohol
Niacin
Valproic acid
Azathioprine
Diuretics

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DI Esophagitis

» BNP TF «

Bisphosphonates
NSAIDs
Potassium chloride
Tetracycline
Ferrous sulphate

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DI agranulocytosis

» Drugs Can Cause Petty Major Collapse of Granulocytes «

Dapsone
Carbamazepine
Colchicine
PTU
Methimazole
Clozapine
Ganciclovir

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DI Aplastic anemia

» Can’t Make New Blood Cells Properly «

Carbamazepine
Methimazole
NSAIDs
Benzene
Chloramphenicol
PTU

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DI lupus

» Lupus Makes My HIPS Extremely Painful «

Methyldopa
Minocycline
Hydralazine
Isoniazid
Phenytoin
Sulfa drugs
Etanacerpt
Procainamide

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DI hemolysis in G6PD

» hemolysis IS D PAIN «

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

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DI megaloblastic anemia

» blast w PMSH «

Phenytoin
Methotrexate
Sulfa drugs
Hydroxyurea

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DI photosensitivity

» SAT for a Foto«

Sulfonamides
Amiodarone
Tetracycline
5-FU

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DI SJS

» CLAPS «

Lamotrigine
Allopurinol
Penicillin
Sulfa drugs
Carbamazepine

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DI seizures

» BITE «

Bupropion
Isoniazid. Imipenem
Tramadol
Enflurane

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DI interstitial nephritis

» 5 Ps «

Pee - diuretics
Pain-free - NSAIDS
Penicillin + cephalosporins
PPIs
rifamPin
Sulfa drugs

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Disulfiram~ reaction

» Sorry Pals, Can’t Go Mingle «

Sulfonylureas
Procarbazine
Cephalosporin, Chloramphenicol
Griseofulvin
Metronidazole

DI nephro / Ototoxicity

» Listen And Pee Very Badly «

Loop diuretics
Aminoglycosides
cisPlatin
Vancomycin
amphotericin B

Rodenticide tox

= Warfarin tox : seen in 48 hours

Tx: FFP (II, VII, IX, X) + Vit K

FFP vs Cryoprecipitate

FFP : II, VII, IX, X

Cryoprecipitate: obtained from FFP by centrifugation - factor VIII, XIII, vWF, Fibrinogen

SE Aspirin

GI bleed
Mucosal injury
Salicylism: vertigo, tinnitus, hearing loss, hyperpnea- Resp alkalosis

DI cold extremities / Raynaud

Amphetamine
Ergotamine
Chemotherapy

DI constipation

1. Opioid 2. Iron supp 3. CCBs 4. AntiCholinergics: Atropine

DI urinary retention

Anticholinergic drugs: 1. TCA: Amitriptyline 2. Antihistamines: Diphenhydramine

DI gynecomastia

» FE SACKS « 1. 5 alpha-reductase inhib: Finasteride 3. Estrogen 4. Spironolactone 5. Antiandrogen: Flutamide 6. Cimetidine 7. Ketoconazole 8. Steroids

DI Angioedema

1. ACEi

DI DCM

Anthracyclines: Doxorubicin - binds w topoisomerase II to cleave DNA - binds w iron to generate free radicals

DI priapism

Sildenafil

DI hearing loss / ototoxicity

1. Loop diuretics 2. Sildenafil 3. Aminoglycosides (children)

DI tinnitus

1. Aspirin

NaHCO3 antidote for?

1. Salicylism: Binds to free H+ to trap aspirin in blood + alkalinize urine to inc elimination 2. TCA: Dec binding of TCA to cardiac Na ch to lower risk of arrhythmia

DI induced altered smell/ taste sensations ``` Metallic taste: Garlic breath: Acetone odor: Bitter almond taste: Peanuts: ```

Metallic taste: Metronidazole Garlic breath: Arsenic, Organophosphates, Acetone odor: Salicylates Bitter almond taste: Cyanide Peanuts: Rat poison

DI osteopetrosis

1. Phenobarbital. Phenytoin. Carbamazepine. 2. Aromatase inhib: 3. PPIs 4. GnRH agonists 5. Steroids

DI B9 def

1. Phenytoin 2. Sulfonamides 3. Methotrexate

DI B6 def

1. Isoniazid | 2. OCP

DI B12 def

1. Metformine

DI gout

1. Thiazides 2. Loop 3. Pyrazinamide 4. Ethambutol

SE TMP-SMX?

1. SJS 2. Hemolytic anemia in G6PD def pts 3. RTA4 5. Photosensitivity 5. Kernicterus on neonates 6. DI lupus 7. Displaces Warfarin from albumin

DI Acute tubular necrosis

1. Aminoglycosides

DI RTA 4

1. Amphotericin | 2. TMP-SMX

DI cardiac Tamponade

1. Hydralazine | 2. Isoniazid

DI non-exertional heatstroke

» B SAD b/c you can’t sweat « 1. AntiCholinergic 2. Sympathomimetics 3. DA antag 4. Diuretics 5. Beta blockers

Muscarine toxicity

- found in mushrooms - inhib M2 + M3 receptors - inc NO synth

Medications to avoid in elderly

Beers criteria » PACE the elderly « 1. - Pain : NSAIDs, Skeletal muscle relaxants, Opioids - PPIs 2. AntiCholinergics: FG antihistamine, GI antispasmodics 3. - CVS: a1 blocker, a-2 agonists, anti-arrhythmics - CNS: TCA, BDZ, barb, Antipsychotics, anti-depressants 4. Endocrine: (long-acting) Sulfonylureas, insulin