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Pharm > Toxicology > Flashcards

Toxicology Flashcards

1
Q

Abx used for Lead + Copper tox

A

Penicillinamine, Trientine

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2
Q

DI Torsades de pointes

A

Aka Polymorphic VTach

» ABCDEF « 
antiArrhythmics (IA, III) + ARSENIC
antiBiotics (Macrolides+ Fluroquinolones)
antiCychotics
antiDepressants (TCA)
antiEmetics (Odansetron)
Fluconazole

— Amiodarone: least risk of QT prolongation d/t homogeneous effect on ventricular repolarization

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3
Q

DI Hyperglycemia

A

» The People Need Hard Candies«

  1. Tacrolimus
  2. Protease inhibitors
  3. Niacin
  4. HCTZ
  5. Corticosteroids
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4
Q

Which drug causes both Hypo + Hyperthyroidism?

A

Amiodarone

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5
Q

DI SIADH

A
  1. Sm cell lung ca
  2. Carbamazepine
  3. SSRIs
  4. Cyclophosphamide
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6
Q

DI Hepatic necrosis

A

» HAVAc «

  1. Halothane
  2. Amanita mushroom
  3. Valproic acid
  4. Acetaminophen
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7
Q

DI Hepatitis

A

» PS RIF «

  1. Pyrizinamide
  2. Statins
  3. Rifampin
  4. Isoniazid
  5. Fibrates
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8
Q

DI pancreatitis

A

» Drugs Causing Sick, Voilent And Nasty Abd Distress «

  1. Didanosine
  2. Corticosteroids
  3. SULFASALAZINE
  4. Alcohol
  5. Niacin
  6. Valproic acid
  7. Azathioprine
  8. Diuretics
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9
Q

DI Esophagitis

A

» BNP TF «

  1. Bisphosphonates
  2. NSAIDs
  3. Potassium chloride
  4. Tetracycline
  5. Ferrous sulphate
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10
Q

DI agranulocytosis

A

» Drugs Can Cause Petty Major Collapse of Granulocytes «

  1. Dapsone
  2. Carbamazepine
  3. Colchicine
  4. PTU
  5. Methimazole
  6. Clozapine
  7. Ganciclovir
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11
Q

DI Aplastic anemia

A

» Can’t Make New Blood Cells Properly «

  1. Carbamazepine
  2. Methimazole
  3. NSAIDs
  4. Benzene
  5. Chloramphenicol
  6. PTU
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12
Q

DI lupus

A

» Lupus Makes My HIPS Extremely Painful «

  1. Methyldopa
  2. Minocycline
  3. Hydralazine
  4. Isoniazid
  5. Phenytoin
  6. Sulfa drugs
  7. Etanacerpt
  8. Procainamide
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13
Q

DI hemolysis in G6PD

A

» hemolysis IS D PAIN «

  1. Isoniazid
  2. Sulfonamides
  3. Dapsone
  4. Primaquine
  5. Aspirin
  6. Ibuprofen
  7. Nitrofurantoin
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14
Q

DI megaloblastic anemia

A

» blast w PMSH «

  1. Phenytoin
  2. Methotrexate
  3. Sulfa drugs
  4. Hydroxyurea
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15
Q

DI photosensitivity

A

» SAT for a Foto«

  1. Sulfonamides
  2. Amiodarone
  3. Tetracycline
  4. 5-FU
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16
Q

DI SJS

A

» CLAPS «

  1. Lamotrigine
  2. Allopurinol
  3. Penicillin
  4. Sulfa drugs
  5. Carbamazepine
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17
Q

DI seizures

A

» BITE «

  1. Bupropion
  2. Isoniazid. Imipenem
  3. Tramadol
  4. Enflurane
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18
Q

DI interstitial nephritis

A

» 5 Ps «

  1. Pee - diuretics
  2. Pain-free - NSAIDS
  3. Penicillin + cephalosporins
  4. PPIs
  5. rifamPin
    Sulfa drugs
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19
Q

Disulfiram~ reaction

A

» Sorry Pals, Can’t Go Mingle «

  1. Sulfonylureas
  2. Procarbazine
  3. Cephalosporin, Chloramphenicol
  4. Griseofulvin
  5. Metronidazole
20
Q

DI nephro / Ototoxicity

A

» Listen And Pee Very Badly «

  1. Loop diuretics
  2. Aminoglycosides
  3. cisPlatin
  4. Vancomycin
  5. amphotericin B
21
Q

Rodenticide tox

A

= Warfarin tox : seen in 48 hours

Tx: FFP (II, VII, IX, X) + Vit K

22
Q

FFP vs Cryoprecipitate

A

FFP : II, VII, IX, X

Cryoprecipitate: obtained from FFP by centrifugation - factor VIII, XIII, vWF, Fibrinogen

23
Q

SE Aspirin

A
  1. GI bleed
  2. Mucosal injury
  3. Salicylism: vertigo, tinnitus, hearing loss, hyperpnea- Resp alkalosis
24
Q

DI cold extremities / Raynaud

A
  1. Amphetamine
  2. Ergotamine
  3. Chemotherapy
25
Q

DI constipation

A
  1. Opioid
  2. Iron supp
  3. CCBs
  4. AntiCholinergics: Atropine
26
Q

DI urinary retention

A

Anticholinergic drugs:

  1. TCA: Amitriptyline
  2. Antihistamines: Diphenhydramine
27
Q

DI gynecomastia

A

» FE SACKS «

  1. 5 alpha-reductase inhib: Finasteride
  2. Estrogen
  3. Spironolactone
  4. Antiandrogen: Flutamide
  5. Cimetidine
  6. Ketoconazole
  7. Steroids
28
Q

DI Angioedema

A
  1. ACEi
29
Q

DI DCM

A

Anthracyclines: Doxorubicin

  • binds w topoisomerase II to cleave DNA
  • binds w iron to generate free radicals
30
Q

DI priapism

A

Sildenafil

31
Q

DI hearing loss / ototoxicity

A
  1. Loop diuretics
  2. Sildenafil
  3. Aminoglycosides (children)
32
Q

DI tinnitus

A
  1. Aspirin
33
Q

NaHCO3 antidote for?

A
  1. Salicylism:
    Binds to free H+ to trap aspirin in blood + alkalinize urine to inc elimination
  2. TCA:
    Dec binding of TCA to cardiac Na ch to lower risk of arrhythmia
34
Q

DI induced altered smell/ taste sensations

Metallic taste:
Garlic breath:
Acetone odor:
Bitter almond taste:
Peanuts:
A

Metallic taste: Metronidazole

Garlic breath: Arsenic, Organophosphates,

Acetone odor: Salicylates

Bitter almond taste: Cyanide

Peanuts: Rat poison

35
Q

DI osteopetrosis

A
  1. Phenobarbital. Phenytoin. Carbamazepine.
  2. Aromatase inhib:
  3. PPIs
  4. GnRH agonists
  5. Steroids
36
Q

DI B9 def

A
  1. Phenytoin
  2. Sulfonamides
  3. Methotrexate
37
Q

DI B6 def

A
  1. Isoniazid

2. OCP

38
Q

DI B12 def

A
  1. Metformine
39
Q

DI gout

A
  1. Thiazides
  2. Loop
  3. Pyrazinamide
  4. Ethambutol
40
Q

SE TMP-SMX?

A
  1. SJS
  2. Hemolytic anemia in G6PD def pts
  3. RTA4
  4. Photosensitivity
  5. Kernicterus on neonates
  6. DI lupus
  7. Displaces Warfarin from albumin
41
Q

DI Acute tubular necrosis

A
  1. Aminoglycosides
42
Q

DI RTA 4

A
  1. Amphotericin

2. TMP-SMX

43
Q

DI cardiac Tamponade

A
  1. Hydralazine

2. Isoniazid

44
Q

DI non-exertional heatstroke

A

» B SAD b/c you can’t sweat «

  1. AntiCholinergic
  2. Sympathomimetics
  3. DA antag
  4. Diuretics
  5. Beta blockers
45
Q

Muscarine toxicity

A
  • found in mushrooms
  • inhib M2 + M3 receptors
  • inc NO synth
46
Q

Medications to avoid in elderly

A

Beers criteria

» PACE the elderly «

    • Pain : NSAIDs, Skeletal muscle relaxants, Opioids
      - PPIs
  2. AntiCholinergics: FG antihistamine, GI antispasmodics
    • CVS: a1 blocker, a-2 agonists, anti-arrhythmics
      - CNS: TCA, BDZ, barb, Antipsychotics, anti-depressants
  4. Endocrine: (long-acting) Sulfonylureas, insulin

Pharm (11 decks)

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