Resp

Question 1

N spirometry followed but what test for Dx?

Answer 1

Methacholine - Bronchoprovocation

Hyperresponsivity in asthmatics

Question 2

Obstructive spirometry followed but what test for Dx?

Answer 2

Bronchodilators: Levabuterol

Before + after
Reversal of obstruction: Asthma

Question 3

PFTs in OLD vs RLD

Answer 3

FEV1/FVC:
Low: OLD
High: RLD

DLCO:
N-inc: Asthma
Dec: COPD, ILD, Granulomatous disease

Question 4

CFTR modulating drugs

Answer 4

1. Lumacaftor
   - restore CFTR proteins to memb
2. Ivacaftor
   - enhance chloride transport

Improves FEV + dec Pulm exacerbations

Question 5

Tx PHTN

Answer 5

1. Endothelin R blockers
2. Nitrates
3. PDE inhibitors
4. Prostacyclin analogs

Vasodilation

Question 6

Regadenoson

Answer 6

Coronary vasodilator used in stress test for CAD Dx

Question 7

Asthma Tx

Answer 7

1. Beta2 blockers: Albuterol, Terbutaline
2. Montelukast, Zafirlukast
3. Zileuton
4. Anti histamines H1
5. Steroids
6. Cromolyn,
7. Theophylline
8. Omalizumab

Question 8

Asthma exacerbation Tx

Answer 8

1. Albuterol
2. Steroids
3. Ipratropium nebulized
4. SC/ IM Epi

Question 9

Antidepressant used for smoking cessation?

Answer 9

Bupropion

Inhibits NE + DA reuptake
- no sexual SE

Question 10

Drugs used for smoking cessation

Answer 10

1. Bupropion

2. Varenicline

Question 11

Mech of drug causing Pulm fibrosis

Answer 11

Bleomycin

DNA synth inhib by causing strand breakage