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Pharm > Endo > Flashcards

Endo Flashcards

1
Q

Antidiabetics causing weight gain

A
  1. Sulfonylureas
  2. Meglitinides
  3. Thiazolidinediones - Pioglitazone
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2
Q

Antidiabetics causing weight loss

A

GLP1 Ag - Exenatide, Liraglutide

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3
Q

Antidiabetics causing hypoglycemia

A
  1. Sulfonylureas

2. Meglitinides

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4
Q

Metformin S.E.

A
  1. Diarrhea

2. Lactic acidosis

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5
Q

Antidiabetics causing edema + HF

A

Thiazolidinediones - Pioglitazone

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6
Q

Antidiabetics causing nasopharyngitis

A

DPP4 inhib - Sitagliptins

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7
Q

Antidiabetics causing inc in C-peptide

A
  1. Sulfonylureas
  2. Meglitinides

Less common w
GLP1 Ag + DPP4 inhibitors

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8
Q

Drug used for DKA

A

Regular insulin IV x rapid control + SC.

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9
Q

Which drugs exacerbate + mask hypoglycemic Sx?

  • MOA
A

NS beta blockers

  • inhibit NE/Epi mediated neurogenic Sx : tremors, tachycardia, anxiety/ arousal but do not inhibit ACh mediated sweating, hunger and paresthesia

0 Neuroglucopenic Sx : dec glucose in CNS- beh changes, confusion, visual disturbance, stupor, seizure

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10
Q

Drugs dec periph conversion of T4 to T3

A
  1. Glucocorticoids
  2. PTU
  3. Beta blockers
  4. Ipodate (contrast agent)
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11
Q

Drugs dec Iodine uptake by thyroid

A

Oxoanions - Perchlorate, Pertechnate

  • inhibit Na-Iodide symporter
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12
Q

Drugs dec iodine organification and coupling?

A

Thioamides - PTU, Methimazole

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13
Q

Which drug inhibits mt glycerophosphate dehydrogenase in liver?

A

Metformin

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14
Q

Drug dec endogenous insulin and C-peptide secretion by dec postprandial hypoglycemia

A

Acarbose

Dec gluc absorbtion

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15
Q

Effect of estrogen in thyroid?

A

Estrogen inc TBG - dec T4+T3 — stimulates thyroid gland to produce new TSH - inc total T4

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16
Q

Drugs dec Uric acid clearance

A
  1. Thiazides
  2. Cyclosporine
  3. Tacrolimus
17
Q

Drugs dec Uric acid levels

A
  1. XO inhib - Allopurinol

2. Probenecid (uricosuric)

19
Q

Anti hyperlipidemics causing inc Triglycerides

A

Bile acid resine - Cholestyramine, Colestipol, Colesevelam

20
Q

Anti hyperlipidemics dec TGL

A
  1. Fibrates - Gemfibrozil, Fenofibrate (I line)
  2. Niacin
  3. Omega 3 FA
21
Q

Tx of post-thyroidectomy hypocalcemia?

A

Calcitriol

22
Q

Drugs dec PTH

A

Cincalcet — activates CASR to dec PTH release:

23
Q

Drugs dec absorbtion of phosphatase

A

Sevelamer

24
Q

Sympathomimeticnagents used for weight loss?

A
  1. Phentermine
  2. Diethylpropion
  3. Benzphentamine
  • release NE
    SE: high wt REGAIN.
    CI: CVD pts
25
Q

Lipase inhibitor used for wt loss

A

Orlistat

26
Q

Antidepressants used for wt loss?

A
  1. Bupropion

2. Naltrexone

27
Q

Anti hyperlipidemics inc HDL?

A
  1. Fibrates

2. Niacin

32
Q

Drugs dec LDL

A
  1. Statis - inc LDL receptor recycling

2. Ezetimibe -

33
Q

Only human recombinant insulin

A
  1. Regular insulin

2. Neutral protamine Hagedorn (NPH)

Pharm (11 decks)

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