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Critical Care 1 > Toxicology > Flashcards

Toxicology Flashcards

1
Q

3 Stages of Tylenol overdose

A
  1. flu-like (N/V, abd pain, swat, pale)
  2. liver injury (RUQ pain, LFT elevate)
  3. peak liver enzymes (hepatic fialure (glucose/lactate/phosphate abnormal), encephalopathy, hypoglyemia, coma, death
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2
Q

late stage serious complications of tylenol overdose

A 
hepatic failure
encephalopathy
hypoglyvemia
coma
death
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3
Q

abnormal labs in tylenol overdose

A

LFT elevated
low glucose
phosphate abnormal

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4
Q

asprin overdose

A

N/V

tinnitis

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5
Q

acid base in asprin overdose

A

r. alkalosis

can progress to m. acidosis

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6
Q

cause of REye’s disease

A

pediatric asprin overdose

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7
Q

complications of asprin overdose

A

liver & brain damage
high ICP possible encephalopathy
hepatic encephalopathy

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8
Q

treatment of asprin overdose

A

sodium bicarb (b/c liver damage causes high ammonia) and dialysis

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9
Q

labs in asprin overdose

A

r. alkalosis progressing to m. acidosis

high lactate b/c liver damage

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10
Q

benzodiazepines

A 
diazepam = valium
lorazepam = ativan
midazolam = versed
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11
Q

treatment of benzodiazepine overdose

A

activated charcoal if ingested

flumazenil

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12
Q

Fluzemanil

A

benzo overdose

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13
Q

pushing Flumazenil too fast

A

seizures

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14
Q

antidoate for Beta Blocker overdose

A

glucagon

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15
Q

s/s of BB overdose

A 
low bp/hr
conduction delays
low glucose
p. edema
bronchospams
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16
Q

glucose in BB overdose

A

low glucose

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17
Q

overdose with low glucose

A

consider BB overdose

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18
Q

treat BB overdose

A

glucagon
pacing, atropiner
IVF for low bp

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19
Q

difference between BB and CaChB overdose s/s

A

both have low HR/BP/conduction delays
BB = low glucose
CaChab= high glucose

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20
Q

s/s CaChB overdose

A

low BP/HR/conduction delays
m. acidosis
high glucose

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21
Q

treatment of CaChB overdose

A

activated charcoal
atropine/pacing
IVF for low BP

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22
Q

s/s of digoxinoversoe

A

flu-like
yellow green halos
risk of high K
slurred upstroke on ERS

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23
Q

avoid if digoxin overdose

A

avoid electricity like pacing/cardioversion

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24
Q

EKG of digoxin overdose

A

slurred upstroke on ERS

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25
use of phenytoin (DIlantin)q
seizures
26
s/s of phenytoin (Dilantin) overdose
SVT, coma, confusion, tremores | DI-like s/s
27
treat phenytoin (Dilantin) overdose
IVF/O2, supportative | maybe gastric lavage
28
s/s of cocaine overdose
chest pain, HTN, seizures, rhabdo
29
treat cocaine overdose
IVF, benzos
30
treat PCP
sedatives. no ketamine b/c delirum can worsen
31
risk of MDMA
overheading low Na serotonin syndrome
32
treat alkalis
copious water
33
treat anticholinergic
phyostigime
34
treat ASA
bicarb
35
treatment BB
glucagon
36
treat CaChB
Calcium gluconate
37
treat cocaine
benzos
38
treat coumadin
vitamin K
39
treat pit viper
CroFab, FabAV
40
treat cyanide
sodium thiosulfate, sodium nitrite/amyl nitrate
41
treat phenytoin
supportative
42
treat ethylene gluycol
IV ethonol or Femepizole
43
treat heparin
protamine sulfate
44
treat hydrocarbons
intubate
45
treat hydrofluoric aicd
calcium gluconate
46
treat INH
pyridoxine (vitamin B6)
47
treat iron
Desferal
48
treat methanol
IV ethanol, Fomenizole
49
treat organophosphates
atropine & 2-PAM
50
atropine & 2-PAM
organophosphates
51
treat alcohol overdose
IV ethanol or Fomepizole
52
Fomepizole
alcohol overdose
53
Desferal
iron overdose
54
amyl nitrite/sodium nitrite/sodium thiosulfate
cyanide
55
glucagon as an antidote
BB
56
what does a tricyclic antidepressant overdose look like
anticholinergic-like
57
EKG of tricyclic antidepressant overdose
widened QRS with prolonged QT
58
treatment of tricyclic antidepressant overdose
bicarb, IVF target pH is 7.5-7.55 vasopressors if refractory low bp
59
how to give rx for iron overdose
Desferan creates rose colored urine and normal once yellow again
60
Antizole
treat toxic alcohols
61
ABG of toxic alcohols
lethal anion-gap acidosis over 16
62
aka antiffreeze
ethylene glycol
63
ethylene glycol
antifreeze
64
windshield wiper fluid
methanol
65
methanol
windshield wiper fluid
66
treat alcohol overdose
IV ethanol, Antizol, hemodialysis
67
complication of hydrocarbons
chemical pneumonitis. decreaed viscosity causes aspiration | DO NOT induce vomiting
68
toxidrome of pesticides
organophosphate = cholinergic toxidrome
69
s/s of cholinergic toxidrome
SLUDGE/DUMBELS oraganophosphates neve gases like sarin & Vx
70
SLUDE/DUMBELS
cholinergic toxidrome/organiophosphates | defecation (GI distress/emesiss)
71
nerve gas s/s
cholinergic toxidrome | SLUDGE/DUMBELS
72
Vx s/s
cholinergic toxidrome | SLUDGD/DUBELS
73
DUMBBELS
``` diarrhea urination miosis bronchorrhea bronchospasm emesis lacrimination laxation sweating ```
74
other s/s of nerve gas & organophosphates
SLUDGE/DUMBBELS | nicotinic stimulation = tachycardiat, HTN, fasciculations, paralysis of respiratoyr muscles
75
death from nerve gas/organophosphates
paralysis of respirtory muscles
76
treat organophosphate overdose
atropine to decrease aireay secreations pralidoxime 2-PAM (crowbar organophophate off of ACh) benzos for seizures
77
how does 2-PAM work
crowbar that takes the organophosphate off of ACh | *for organophosphate/nerve agent/cholinergic
78
atropine overdose
anticholinergic
79
benadryl overdose
anticholinergic
80
tricyclic antidepressant overdose
anticholinergic
81
`mad as a hatter....
anticholinergic overdose
82
anticholinergic toxierome s/s
``` mad as a hatter - AMS blind as a bat -mydrisasis red as a beet hot as a hare dry as a bone ```
83
rx for anticholinergic overdose
benadryl/atropine, tricyclic antidpressants... atropine for secreations physostigimine pushed 1mg/min
84
most important intervention for poisionings/overdose
revert back to ABC & antidote

Critical Care 1 (13 decks)

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