Toxicity

Question 1

Features below are consistent with toxicity to which drug?

Confusion, nausea, visual halos and arrthymias.

Answer 1

Digoxin

Question 2

Features below are consistent with toxicity to which drug?

Tremor, arrthymia, seizure, renal failure, diabetes insipidus

Answer 2

Lithium

Question 3

Features below are consistent with toxicity to which drug?

Gum hypertropy, ataxia, nystagmus, peripheral neuropathy

Answer 3

Phenytoin

Question 4

Features below are consistent with toxicity to which drug?

Ototoxicity and nephrotoxicity

Answer 4

Gentamin and vancomycin

Question 5

How do you manage over anticoagulation with warfarin? INR:
<6
6-8
>8

Answer 5

<6 - reduce warfarin dose

6-8 - omit warfarin for 2 days and then reduce dose

> 8 - omit warfarin and give 5-10mg oral vitamin K.

Question 6

What’s the protocol with warfarin if there was a major bleed eg into the brain?
Minor bleed and INR >5?

Answer 6

• stop warfarin
• give 5-10mg IV vitamin K
• give prothrombin complex (beriplex)

Minor bleed-
Give 1-3mg IV vitamin k.

Question 7

What’s the treatment for anti psychotic induced acute dystonic crisis?

Answer 7

1) procyclidine 10mg IV

2) diazepam

Question 8

What drug over dose gives tinnitus?

Answer 8

Aspirin