Toxicity

Question 1

What factors of a substance affect the probability of exposure to a toxic substance?

Answer 1

Nature and form of substance
Solubility
Particle size
Vapour pressure
Degree of exposure
Routine of exposure

Question 2

What factors affect the toxic effect of a substance?

Answer 2

Nature and form of substance

Dose

Route of entry

It’s absorption, distribution, metabolism
and excretion

Question 3

What forms can a hazardous substance take?

Answer 3

Solid
Liquid
Gas
Vapour
Fume
Mist

Question 4

What is the dose?

Answer 4

The amount of chemical that enters the body

Exposure concentration x time

Question 5

What are the 3 main routes of entry into the body for toxins?

Answer 5

Ingestion
Inhalation
Absorption

Question 6

Why is size of particles important with inhaled toxins?

Answer 6

It determines whether the particle is inhalable or respirable. And also whether it can be absorbed into the blood.

Question 7

What are the three parts to toxin distribution?

Answer 7

Storage
Biotransformation
Excretion

Question 8

What are the primary sites for toxins storage in the body?

Answer 8

Adipose tissue
Bone
Liver
Kidneys

Question 9

How can metabolism help the body and where does it occur?

Answer 9

Can render toxic substances non-toxic and occurs primarily in the liver.

Question 10

How are toxins usually ingested in an industrial environment?

Answer 10

Through inhalable toxins climbing the mucociliary escalator and then being digested.