TORCHeS Infections Flashcards
Congenital Toxoplasmosis appearance in neonates
Classic triad of
1) chorioretinitis
2) hydrocephalus
3) diffuse intracranial calcifications
Also shows the blueberry rash
Diagnosis
- IgM antibodies + for Toxoplasmosis Gondi
- also can get PCR for toxoplasmosis DNA to confirm
Treatment = pyrimethamine, sulfadiazine and folinic acid
Congential syphillus appearance in neonates
Early (<2 yrs)
- jaundice and hepatosplenomegaly
- maculopapular rash
- excessive “snuffles”/ nasal discharge
- skeletal abnormalities and lymphadenopathy
Late (>2yrs)
- frontal bossing
- Hutchinson teeth
- interstitial keratitis
- sensorineural deafness
- saber shins
Diagnosis
- VDRL and RPR w/ dark-field microscopy on culture
Treatment = pencilin- G
Congential listeriosis apperance
Usually presents with granulomatosis infantiseptica (vesicular and pustular skin lesions w/ menigitis and sepsis)
is known to cause spontaneous abortions and premature birth
Diagnosis
- bacterial culture in cold temps on blood agar (shows B-hemolysis)
- also CSF fluid will show bacterial cultures for listeriosis
Treatment ampicillin and gentamicin
Congenital VZV apperance
Shows:
- encephalitis
- cataracts and chorioretinitis
- pneumonia
- hypoplastic limbs
- CNS abnormalities
- “ hypertrophic scarring” (cicatial lesions)
**most common in 1st and 2nd trimester if infected
Diagnosis = DFE or PCR for VZV DNA
- can also do serology for IgM antibodies to VAV
Treatment = VZIG shots with acyclovir
Parvovirus B19 apperance
Presents with
- severe fetal hydrops
- aplastic crisis (severe anemia)
Very heavily tied to abortions
Diagnosis
- PCR for B19 DNA
- serial US to rule out or in fetal hydrops syndrome
Treatment = intrauterine fetal blood transfusion
Rubella congential apperance
Presents with
- sensorineural deafness
- cataracts neonatal
- PDA or pulmonary artery stenosis heart murmurs
- CNS abnormalities
Shows the classic blueberry muffin rash
Diagnosis
- serology = IgM antibodies
- PCR for rubella RNA
Treatment = supportive care and hope they survive
CMV congenital apperance
Symptoms
- sensorineural deafness
- periventricular calcifications
- petechiae and purpura (blueberry muffin rash)
- seizures
- small weight and size
Diagnosis
- viral cultures
- PCR = CMV DNA
Treatment = ganciclovir or valganciclovir
HSV congenital appearance
Symptoms
- premature birth and IUGR
- vesicular lesions
- keratoconjuctivits
- sepsis
- meningeoencephalitis
Treatment
- viral culture
- PCR = HSV DNA
Treatment
- Acyclovir
- supportive care
