Topic 5 - Overview of Adaptive Immunity

Question 1

Epitope

Answer 1

• (= antigenic determinant) or specific portion of an entire antigen
  
  • T and B cell receptors are specific for a single epitope

Question 2

Antigenic Determinant

Answer 2

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Question 3

Peptide

Answer 3

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Question 4

Somatic Recombination

Answer 4

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Question 5

Negative Selection

Answer 5

• Somatic Recombination occurs in primary lymphoid tissues in the absence of antigen.
• The drawback of not designating a specific individual immune receptor for each infectious agent is that it has the capacity to generate***
  
  • **1.) It generates reactivity to self (very RISKY)
    a. Dealt with by NEGATIVE SELECTION

Ex.) Antigen (epitope) recognition by T-lymphocyte is a portion (epitope) of your own Thyroid Stimulating Hormone receptor.
- Leads to Autoimmune response
- Luckily NEGATIVE SELECTION prevents this
= b/c it is a process that removes B/T lymphocytes that have potential to respond to self antigen.

Question 6

Positive Selection

Answer 6

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Question 7

Clonal selection

Answer 7

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Question 8

Antibody (Ab)

Answer 8

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Question 9

Immunoglobulin (lg)

Answer 9

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Question 10

Antibody class

Answer 10

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Question 11

Antibody isotype

Answer 11

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Question 12

Humoral immunity

Answer 12

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Question 13

Cellular (cell mediated) immunity

Answer 13

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Question 14

BCR

Answer 14

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Question 15

TCR

Answer 15

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Question 16

MHC (major histocompatibility complex)

Answer 16

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Question 17

Describe the type of antigens that T lymphocytes and B lymphocytes are able to bind.

Answer 17

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Question 18

Know Structures of B and T lymphocyte receptors

• Identify light chains
• Identify heavy chains
• Variable region
• Constant region
• Alpha chain
• Beta chain
• Antigen binding sites

Answer 18

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Question 19

Identify whether the variable regions or constant regions of the T cell and B cell receptors function in antigen binding or are responsible for the effector function.

Answer 19

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Question 20

List the approximate number of T lymphocytes or B lymphocytes that should be able to respond to a given antigen the first time your body is exposed to that antigen.

Answer 20

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Question 21

List and briefly describe the 2 main functions of antibodies

Answer 21

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Question 22

List the two T cell co-receptor molecules and whether they bind to MHC class 1 or MHC class 2 molecules.

Answer 22

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Question 23

List the main functions of each of the 3 effector T cells (Th1, Th2, Tc) and be able to identify whether they possess CD4 or CD8 on their surface.

Answer 23

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