Topic 2 - Adaptive Immunity: Lymphoid Tissues Flashcards
Primary lymphoid tissue
- Bone marrow & Thymus
~Where Lymphocytes grow up!
~Where develop their antigen receptors and undergo testing to make sure that they are going to be functional, not harmful to self.
Secondary lymphoid tissue
- Occur in “beads on a string” like orientation
- Eventually drain back into the Subclavian vein.
Lymph
-Colorless fluid containing white blood cells that bathes the tissues and drains through the lymphatic system and into the blood stream.
Naive lymphocyte
-A naive B cell is a B cell that has not been exposed to an antigen. Once exposed, it becomes a memory B cell, the first step in developing learned immunity to an infectious agent.
PALS (periarteriolar lymphoid sheath)
- Lymphocytes can become activated in the Spleen.
- Where lymphocytes respond to pathogens carried in the blood.
- Spleen tiss. cont. Red and White pulp-(Imm. syst of spleen)
- T-Cells are primarily located in the PALs surrounding the central arteriole.
GALT
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BALT
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MALT
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M cell
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List 2 tissues/organs that represent the primary lymphoid tissues
- Bone Marrow
2. Thymus
Describe how a naive lymphocyte enters a lymph node, and how it would exit if it did not get stimulated by antigen
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Describe how antigen enters a lymph node
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List where T lymphocytes and B lymphocytes are primarily located in the lymph nodes and the white pulp of the spleen
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What are the main advantages of the adaptive immune response
Immune Memory
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Describe the primary and secondary responses to an antigen/infection
- including the relative amount of antibody produced
- the speed at which the antibody is produced (hours or days), and in the process, define what is meant by lag phase
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