Topic 5 - autoimmune, rheumatologic conditions and chronic pain Flashcards
SLE (systemic lupus erythematosus) is an autoimmune disease that leads to …
chronic tissue / organ inflammation
What are the acute and chronic symptoms of NPSLE
acute: psychosis, CVA and myelopathy
chronc: headaches and cognitive dysfunction
What are the risk factors for cognitive dysfunction in SLE
hypertension, obesity and age
How is SLE treated?
with glucocorticosteroids
What cognitive dysfunctions are associated with SLE?
verbal fluency, visuospatial abilities, memory, attention and EF
What is rheumatic arthritis?
an autoimmune disease that manifests primarily as symmetric inflammation of multiple joints
What neuropsychological impairments are associated with RA?
attention, memory and executive function
What is sjogren syndrome?
chronic autoimmune disease that targets exocrine glands
What are the main symptoms of sjogren?
dry mouth and dry eyes
What neuropsychological impairments are associated with sjogren?
memory, executive function and attenion
What is fibromyalgia?
a disorder characterized by widespread muscuskeletal pain and the presence of at least 11 of 18 well-defined tender points with no clinical marker of pathology
Neuropsychological deficits in fybromyalgia?
memory (working memory, episodic memory and verbal fluency) and concentration problems
What is Chronic fatigue syndrome?
a syndrome defined by long-standing (> 6 months) fatique that is not resolved with rest, and the presence of four or more other symtpoms, that can include self-reported cognitive impairment
Most consistent findings in CFS
information processing speed, information processing efficiency, concentration and motor speed are most impaired
What kind of abnormalities have been found in CFS?
abnormalities in white matter, reduced global global gray matter, reduced cerebral blood flow in frontal and occipital lobes.
