topic 3b - lysogenic lifecycle

Question 1

what enzyme is always needed during this cycle?

Answer 1

integrase

Question 2

what are the steps of this cycle?

Answer 2

step 1 - attachmentstep 2 - penetration step 3 - incorporation step 4 - synthesis step 5 - assembly step 6 - release

Question 3

What steps are different from the lytic cycle?

Answer 3

step 3 - incorporation step 4 - synthesis

Question 4

what is step 3: incorporation?

Answer 4

-viral genes join host cell genome (using integrase)

Question 5

what is the incorporated virus now called?

Answer 5

provirus (or prophage if bacteriophage)

Question 6

what is the drug target of incorporation?

Answer 6

drug: integrase inhibitors - would stop the binding of the viral genes to the host genome

Question 7

what are some of the triggers that activate expression of viral genes?

Answer 7

• chemical, physical, or emotional TRAUMA -
  age (older
• hormones (menstrual, pregnancy, steroids)
• other illnesses (“cold sores”)
• UV radiation (“sun poisoning”)
• AA agrinine (higher ration w/ aa lysine)

Question 8

what is the difference between the synthesis step of lyic and lysogenic cycles?

Answer 8

• lysogenic starts with proviral DNA no matter what genome type virus

Question 9

what is the drug target for the synthesis step?

Answer 9

drug: reverse transcriptase inhibitors