Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHAN 1 LEC > TOPIC 2: Methods of Analysis and Pharmacopeia > Flashcards

TOPIC 2: Methods of Analysis and Pharmacopeia Flashcards

1
Q

4 Classification of Analysis

A

Based on sample size
Based on the extent of determination
Based on nature of methods
Based on materials used

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

< 1 mg sample size

A

Ultramicroanalysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

1mg - 10mg sample size

A

Microanalysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

10mg - 100mg

A

Semi-microanalysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

100mg - 1g

A

Macroanalysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Faster type of analysis

A

Ultramicroanalysis
Microanalysis
Semi-microanalysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Proximate analysis is?

A

General

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Total amount of a class or a group of active plant principles in a given sample.

Ex: Carbohydrates and Proteins (amino acids)

A

Proximate analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Composition of a mixture of different compounds.

A

Proximate analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Proximate analysis have _____ accuracy.

A

Low

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ultimate analysis is?

A

Specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Amount of a specific constituent or a single chemical species present in the sample.

A

Ultimate analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Elemental composition of a chemical compound.

A

Ultimate analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ultimate analysis have _____ accuracy.

A

High

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

3 Methods of Analysis

A

Classical Method
Instrumental Method
Miscellaneous / Special Method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Under Volumetric Method

A

Acid-base titration
Precipitation
Complexometric
Redox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Under Gravimetric Method

A

Direct
Indirect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Under Optical Method

A

Spectrophotometry
Polarimetry
Nephelometry
Turbidimetry
Raman scattering

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Under Electroanalytical Method

A

Potentiometry
Voltammetry
Conductometry
Coulometry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Under Classical Method

A

Volumetric
Gravimetric

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Under Instrumental Method

A

Optical
Electroanalytical
Thermal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Classical Method is also known as?

A

General / Chemical / Wet / Stoichiometric Method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Classical Method uses ?

A

reagents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Types of Quantitative Analysis

A

Volumetric Analysis
Gravimetric Analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

It is an analysis involving the measurement of VOLUME of a solution of known concentration required to react with the desired constituent.

A

Volumetric Analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

It is an analysis involving the accurate measurement of WEIGHT by making it react quantitatively with another substance usually a precipitant.

A

Gravimetric Analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Gravimetric in Latin?

A

gravitas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Most common method is precision.

A

Gravimetric Analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Instrumental method is more accurate because of?

A

calibrated instruments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

This method is based on specific physical or chemical properties of the analyte.

A

Instrumental Method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Examples of Instrumental Method

A

Spectrometry (most common)
Polarimetry
Chromatography

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Most common instrumental method?

A

Spectrometry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

This method is based upon the measurement of the interaction of the molecules with electromagnetic radiation/light.

A

Optical Method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Optical method is also known as the ______________ method of analysis.

A

physicochemical method of analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Amount of light absorbed.

A

Spectrophotometry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Defined as the process of separation of the individual components of a mixture based on their relative affinities towards stationary and mobile phases.

A

Chromatography

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Equipment has detectors that follows the rule of ?

A

Spectrometry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Example of Chromatography

A

HPLC (High-performance liquid chromatography)

39
Q

Measurement of the angle of rotation of the plane of polarized light/ amount of light rotated.

A

Polarimetry

40
Q

Measurement of bending of light.

A

Refractometry

41
Q

Works by measuring the potential (volts) and/or current (amps) in an electrochemical cell containing the analyte.

A

Electrochemical methods

42
Q

Example of Electrochemical Method

A

Potentiometry (pH meters)

43
Q

Refers to group of techniques in which a physical property of a substance is measured as a function of temperature while the substance is subjected to a controlled temperature program.

A

Thermal Method

44
Q

Example of Thermal method is _________________ (uses temperature by measuring the difference in weight BEFORE and AFTER heating samples.

A

Thermogravimetric analysis

45
Q

Difference in weight in thermogravimetric analysis is equal to?

A

Difference in weight = loss amount of moisture

46
Q

Involves the crude drugs and other natural products.

A

Miscellaneous / Special Method

47
Q

Not common test on chemical drugs.

A

Miscellaneous / Special Method

48
Q

Examples of Miscellaneous or Special Method

A

Acid value
Ash content
Water content

49
Q

Based on the materials used

Chemical =

A

Titrimetric method

50
Q

Based on the materials used

Physical =

A

Instruments and special apparatuses

51
Q

Based on the materials used

Biological =

A

Use of microorganism and animals and parts thereof

52
Q

Examples of Biological Methods/Assay

A

Rabbit - assay of Insulin and Tubocurarine

Cat - assay of Glucagon inj.

Pigeon - assay of Digoxin

Chicken - assay of Oxytocin

53
Q

Lowers blood sugar.

A

Insulin

54
Q

Used as muscle relaxant.

A

Tubocurarine

55
Q

Increases blood sugar.

A

Glucagon

56
Q

Used to increase pumping of heart.

A

Digoxin

57
Q

Oxytocin hormone is present to stimulate ________________ during labor / to prevent bleeding.

A

uterine contraction

58
Q

Fever causing substance.

A

Pyrogen

59
Q

References used for decision making for analysis.

A

Drug References

60
Q

Approved sources of guidelines for drug quality required by certain practitioners or agencies.

A

Official Compendia

61
Q

Pharmacopoeia is created from two Greek words ?

A

pharmakon (drug) & poiein (to make)

62
Q

Comprises LIST of pharmaceutical substances, formula along with their description and standards.

A

Pharmacopoeia

63
Q

Philippine Pharmacopeia consists of ____ volumes.

A

2 volumes

64
Q

Volume 1 focuses more on?

A

Chemical drugs

65
Q

Volume 2 focuses more on?

A

Crude drugs

66
Q

Drugs that undergone the
process of collection and drying.

A

Crude drugs

67
Q

Creation to signing of the first Philippine Pharmacopeia in cooperation with the Japanese Government through the initiatives of Dr. Conrado S Dayrit and Prof Akira Hamada.

A

1996

68
Q

Creation Pharmacopeia Organization for preparation and publication of the Phil Pharmacopeia thru Department Order 216

A

1999

69
Q

Declaring and adopting the Phil Pharmacopeia as the Official book of Standards and Reference for Pharmaceutical Products and Crude plant drugs in the Philippines.

A

2004

70
Q

British Pharmacopeia

Medical Act of 1858 published the first COMBINED Pharmacopeia (London, Edinburgh and Dublin)

A

1864

71
Q

British Pharmacopeia

BP edition included monographs of materials used for Traditional Chinese medicines

A

2007

72
Q

British Pharmacopeia

Revision is annual and is made official every 1st of January each year.

A

2008 - present

73
Q

Date when Japan Pharmacopeia was published.

A

June 25, 1886

74
Q

International Pharmacopeia was published in the year ______ by WHO in cooperation with United Nations.

A

1951

75
Q

European Pharmacopeia

A

1969

76
Q

The first American formulary compiled by Gen William Brown was so called “____________,” published at Lititz, Pennsylvania, for use by the Military Hospital of the United States Army.

A

Lititz Pharmacopeia, 1778

77
Q

The first US Pharmacopeia through the efforts of :Dr. Lyman Spalding, Dr. Samuel Mitchill and Dr. Jacob Bigelow.

A

1820

78
Q

In 1888, First National Formulary was published by ?

A

American Pharmacists Association

79
Q

President Theodore Roosevelt signed into law the first Federal Pure Food and Drug Act and changed the title to National Formulary, designating both USP and NF as establishing legal standards for medical and pharmaceutic substances.

A

1906

80
Q

USP acquires NF and Drug standards Laboratory from APhA.

A

1975

81
Q

First combined USP-NF was published.

A

1980

82
Q

USP revised and published annually, made official every 1st of May each year.

A

2000

83
Q

_____ onwards, USP-NF is available only in ONLINE format.

A

2020

84
Q

Last print edition of USP-NF

A

USP 43- NF 38

85
Q

The section which presents the basic assumptions, definitions, and default conditions for the interpretation and application of the United States Pharmacopeia (USP) and the National Formulary (NF).

A

General Notices Section

86
Q

General Notices: Topics

A
  1. Monographs and General chapters
  2. Monograph components
  3. Testing practices and procedures
  4. Test results
  5. Terms and definitions
  6. Prescribing and dispensing
  7. Preservation, packaging, storage and labeling
87
Q

What general chapter?

Physical tests and determinations, microbiological tests, Chemical tests and assays, Biological tests and assays.

ENFORCEABLE

A

1 to 999

88
Q

What general chapter?

General Information (no mandatory requirement)

A

1000 to 1999

89
Q

What general chapter?

Apply to articles classified as Dietary ingredient or supplements.

A

Above 2000

90
Q

What general chapter?

Apply to articles classified as Dietary ingredient or supplements.

A

Above 2000

91
Q

Provides a specification by way of a name, definition, description, tests, procedures, and acceptance criteria and sometimes packaging and labeling requirements.

A

Monograph

92
Q

The USP-NF is a combination of two official compendia:

A

the United States Pharmacopeia (USP) and the National Formulary (NF)

93
Q

Parts of a Monograph

The complete monograph of a raw material or a finished dosage form includes the following information:

A
  1. chemical structure
  2. chemical name
  3. purity rubric
  4. packaging and storage
  5. reference standard
  6. Identification tests
  7. Corresponding tests for chemical and physical constants such as melting range, rotatory power, refractive index etc.
  8. Water content
  9. Assay procedure- determination for specific quantity
94
Q

Parts of Monograph for FPP

A

(no chemical structure)

  1. chemical name
  2. purity rubric
  3. packaging and storage
  4. reference standard
  5. Identification tests
  6. Corresponding tests for chemical and physical constants such as melting range, rotatory power, refractive index etc.
  7. Water content
  8. Assay procedure- determination for specific quantity

PHAN 1 LEC (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions