Topic 2

Question 1

Modern Concept

Answer 1

Morawitz

Question 2

Included the thromboplastin generation and its activity

Answer 2

Modern concept

Question 3

Conversion of prothrombin to thrombin

Answer 3

Waterfall theory

Question 4

Waterfall theory

Answer 4

Dacie & Ratnoff

Question 5

4 phases of coagulation

Answer 5

Contact Phase
Activation if factor x to xa
Conversion of prothom to throm
Conversion of fibrinogen to fibrin

Question 6

End point of coag

In vivo

Answer 6

Stable fibrin clot

Question 7

End point of coag

In vitro

Answer 7

Fibrin polymer

Question 8

Cascade theory

Answer 8

Macfarlane

Quick & Howell

Question 9

Marks critical event in hemostatic process

Answer 9

Thrombin formation

Question 10

physiologic Inhibitor

Glycoprotein produced in the liver

Answer 10

Protein C

Question 11

physiologic Inhibitor

Major inhibitor of blood coagulation

Answer 11

Protein C

Question 12

physiologic Inhibitor

Initiated by thrombin a part if the thrombomodulin platelet receptor complex in the presence of calcium ions

Answer 12

Protein C

Question 13

physiologic Inhibitor

Vitamin K dependent

Answer 13

Protein C

Question 14

physiologic Inhibitor

Inactivates factor 8:C and Va in the presence of cofactor protein S

Answer 14

Protein C

Question 15

Vitamin k dependent protein also produced in the liver

Answer 15

Protein S

Question 16

Serves as cofactor for factor c

Answer 16

Protein S

Question 17

Only 40% in the free form

Answer 17

Protein S

Question 18

Remaining 60% is bound to the complement protein C4 binding protein and is not functionally active

Answer 18

Protein S

Question 19

Forms complex wt thrombin, kallikrein thus inhibiting their activities

Answer 19

Alpha2 macroglobulin

Question 20

A slow reacting thrombin inhibitor

Answer 20

Alpha1 antitrypsin

Question 21

Inhibits factor Xia and Xa

Answer 21

Alpha1 antitrypsin

Question 22

Inhibits protein C. This is more active when heparin in present

Answer 22

Activated proteinC inhibitor

Question 23

Modifies the action of thrombin to act more as inhibitor

Answer 23

Thrombomodulin endothelial cell thrombin receptor

Question 24

Essential in vivo and in vitro activation of heparin

Answer 24

Antothrombin III

Question 25

Major inhibitor of thrombin and factor Xa

Answer 25

Antothrombin III

Question 26

It has limited inhibitory activity against factor 9s, 10a, 11a, 12a, kallikrein and plasmin

Answer 26

Antothrombin III

Question 27

Alone it acts vey slowly

Answer 27

Antothrombin III

Question 28

Bids with heparin And greatly enhances the rate of its activity up to 2000x

Answer 28

Antothrombin III

Question 29

Inhibits thrombin and enhanced by heparin

Answer 29

Heparin factor II

Question 30

Lipoprotein associates coagulation inhibitor

Answer 30

Extrinsic pathway inhibitor EPI

Question 31

Inactivates factor XIIa and plasma kallikrein, factor Xa and plasmin

Answer 31

C1 inhibitor

Question 32

Primary inhibitor of plasmin
Present also in platelets and plasma
Very fast effect

Answer 32

Alpha 2 antiplasmin

Question 33

Inactivates plasmin that is nit inhibited by alpha 2 antiplasmin

Answer 33

Alpha 2 macroglobulin

Question 34

Released by platelets

Inhibits activation of fibrin bound plasminogen

Answer 34

Thrombospondin

Question 35

Naturally occurring
They came from enothelial cells and platelets
Deactivates t-PA and urokinase

Answer 35

Plasminogen activtor inhibitor

Question 36

Naturally occuring

Answer 36

Plasminogen inhibior activator 2

Question 37

When present, will inactivate therapeutic streptokinase

Answer 37

Anti-streptokinase antibodies