Topic 2 Flashcards
Modern Concept
Morawitz
Included the thromboplastin generation and its activity
Modern concept
Conversion of prothrombin to thrombin
Waterfall theory
Waterfall theory
Dacie & Ratnoff
4 phases of coagulation
Contact Phase
Activation if factor x to xa
Conversion of prothom to throm
Conversion of fibrinogen to fibrin
End point of coag
In vivo
Stable fibrin clot
End point of coag
In vitro
Fibrin polymer
Cascade theory
Macfarlane
Quick & Howell
Marks critical event in hemostatic process
Thrombin formation
physiologic Inhibitor
Glycoprotein produced in the liver
Protein C
physiologic Inhibitor
Major inhibitor of blood coagulation
Protein C
physiologic Inhibitor
Initiated by thrombin a part if the thrombomodulin platelet receptor complex in the presence of calcium ions
Protein C
physiologic Inhibitor
Vitamin K dependent
Protein C
physiologic Inhibitor
Inactivates factor 8:C and Va in the presence of cofactor protein S
Protein C
Vitamin k dependent protein also produced in the liver
Protein S
Serves as cofactor for factor c
Protein S
Only 40% in the free form
Protein S
Remaining 60% is bound to the complement protein C4 binding protein and is not functionally active
Protein S
Forms complex wt thrombin, kallikrein thus inhibiting their activities
Alpha2 macroglobulin
A slow reacting thrombin inhibitor
Alpha1 antitrypsin
Inhibits factor Xia and Xa
Alpha1 antitrypsin
Inhibits protein C. This is more active when heparin in present
Activated proteinC inhibitor
Modifies the action of thrombin to act more as inhibitor
Thrombomodulin endothelial cell thrombin receptor
Essential in vivo and in vitro activation of heparin
Antothrombin III
Major inhibitor of thrombin and factor Xa
Antothrombin III
It has limited inhibitory activity against factor 9s, 10a, 11a, 12a, kallikrein and plasmin
Antothrombin III
Alone it acts vey slowly
Antothrombin III
Bids with heparin And greatly enhances the rate of its activity up to 2000x
Antothrombin III
Inhibits thrombin and enhanced by heparin
Heparin factor II
Lipoprotein associates coagulation inhibitor
Extrinsic pathway inhibitor EPI
Inactivates factor XIIa and plasma kallikrein, factor Xa and plasmin
C1 inhibitor
Primary inhibitor of plasmin
Present also in platelets and plasma
Very fast effect
Alpha 2 antiplasmin
Inactivates plasmin that is nit inhibited by alpha 2 antiplasmin
Alpha 2 macroglobulin
Released by platelets
Inhibits activation of fibrin bound plasminogen
Thrombospondin
Naturally occurring
They came from enothelial cells and platelets
Deactivates t-PA and urokinase
Plasminogen activtor inhibitor
Naturally occuring
Plasminogen inhibior activator 2
When present, will inactivate therapeutic streptokinase
Anti-streptokinase antibodies
