Hemostasis Flashcards
Process whereby on vessel injury, plasma proteins, tissue factors and calcium interact on the surface on the platelet to form fibrin clot
Coagulation
3 plasma proteins
Collagen, ADp, epithelial cells
Acid-Base coagulation
Homeostasis
Fibrin clots are digested by plasmin
Fibrinolysis
Serum is separated from clotted blood. Due to actomyosin: thrombosthenin
Clot reaction
Abnormal bleeding, decreased activity of coagulation factors
Hypocoagulation
Due to defect/lack of activation of fibrinolytic system
Hypercoagulation
Active enzyme site
Serine protease
Enzyme that catalyzes the conversion of prothrombin to thrombin
Prothrombinase
No biological activity until converted to active enzymes by serine proteases
Zymogens
Substance assist in activation of zymogens
Cofactor
Transmembrane glycoprotein on endothelial cells which serve as a sort of sink for circulation thrombin molecules
Thrombomodulin
Presence of hemoglobin in urine
Hemoglobinuria
Blood in urine
Hematuria
Red pinpoint spots
Petechiae