Topic 2 Flashcards
1
Q
Protein Sequences
A
- determines how a protein folds
- determines how 2 proteins interact
- one codon change= mutation of the sequence
2
Q
Protein Shape
A
- shape of a protein can often tell you about its function
3
Q
Proteins are Polymers of Amino Acids
A
- depending how monomers are linked together can change the protein
4
Q
Generic Structure of an Amino Acid
A
- carboxylate group
- side chain
- amino group
5
Q
Side Chain
A
- changing the side chain will change from one amino acid to another
- if the side chain is glycine, this molecule will be symmetrical (achiral)
6
Q
Amino Group
A
- all amino acids except for glycine have a chiral structure
- only L-forms of amino acids can be used to make a protein
7
Q
How Amino Acids are Linked
A
- linked via condensation reactions
8
Q
Condensation Reactions
A
- removal of a water molecule
- very specific
- requires lots of enzymes
- when the water molecule is removed, it creates a peptide bonds
9
Q
Peptide Bonds
A
- very strong
-covalent - bond forms between an amino group of one AA and a carboxyl group of another AA
10
Q
Residues
A
- Amino acids that are connected by peptide bonds
- START: N-terminus (amino group)
- END: C- terminus (carboxyl group)
11
Q
When Naming From a Structure
A
- determine peptide bond
- determine n-terminus
- determine c-terminus
- look at side chains and determine what is what
12
Q
A PKA Value
A
- describes an acid’s tendency to ionize
13
Q
Lower PKA
A
- higher tendency to ionize
- stronger acid (lower affinity for proton)
14
Q
Higher PH
A
- lower concentration of Hydrogen molecule
15
Q
Smaller PKA
A
- larger Ka value
