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كلاس ٣ > Topic 14 > Flashcards

Topic 14 Flashcards

1
Q

Composition of bone contain 2 Parts?

A
  • Cellular
  • ECM
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2
Q

Mention cellular parts of bone?

A

Cellular: osteoblast osteocyte osteoclast

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3
Q

Function of osteoblast

A

I_produce ECM
2- mineralize ECM
3- Produce osteoid
4- Activation osteoclast
5- Production GH

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4
Q

osteocyte is matured (?) in bony matrix.

A

OB

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5
Q

osteoclast produce (?) with degrade (?)

A

Ht
Hydroxy-apatite

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6
Q

ECM contain (?) and (?)

A

organic
inorganic

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7
Q

mention organic part of ECM of bone cell?

A

Collagen Fiber type I
osteonectin
osteocalcin
proteoglycan
glycosaminoglycans
lipid

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8
Q

inorganic Part of ECM of bone cell?

A

Hydroxyapatite

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9
Q

biological principle of bone regeneration?

A

1- osteogenesis
2- osteo induction
3- osteo Conduction
(◦ steo. gig

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10
Q

biological process for bone regeneration?

A
  • Hematoma formation
  • information and tissue replacement
  • Callus formation (soft and Hard)
  • Consolidation
  • Bone Remodeling
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11
Q

Hematoma formation 7

A
  • mass of blood clot and hemmorhage at site of fracture.
  • at this time site become swallower - painful_ inflamed.
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12
Q

Hematoma formation? (

A
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13
Q

2- information and tissue regeneration
happen in (?) and what cells coming?

A
  • Next few hours.
  • migration of mesenchymal stem cells.
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14
Q

in Inflammatory phase after migration of mesenchymal cells
they produce (?) (?) (?)

A
  • TGF-B
  • PDGF
  • various BMP factors
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15
Q

PDGF full name and function?

A
  • Planet derived Growth factor
  • Stimulate cell cycle
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16
Q

what is callus formation?

A

Fibro cartilaginous callus forms.

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17
Q

Granulation tissue def?

A

Soft callus, forms a few days after fracture
at this time capillaries grow into the tissue and
phagocytic cells begin creating debris

18
Q

Granulation tissue is located at what level
of bone regeneration.?

A

phase of callus formation

19
Q

Consolidation phase?

A

in this stage, New bone trabecular appear
in the fibro cartilage nus callus.
Convert to bony callus occur in 3-4 weeks after
injury and antinous until firm union is formed
2-3 month-

20
Q

Regarding bone Remodeling?

A

in the final stage, excess material on the bone shaft
exterior and medullary canal is removed. here compact bone reconstruct
shaft wall.

21
Q

Remodeling and Modeling:
Remodeling happen in 2 times when?

A

1- During bone formation
2- replace old bone with New bone.

22
Q

in the Remodeling and during bone formation:
primary bone is substitute with Lamela/ bone.
what is primary bone?
what is La.me/ar bone?

A
  • primary bone is woven bone ⇒ low load bearing
  • high load bearing capacity.
23
Q

bone formation is done with osteoblast, vessel, and (?)

A
  • pericyte.
24
Q

Exudative, proliferative phase: day ( ?)

A
  • day 1-14
25
Q

formation of reticular bone:

A
  • week 2-6
26
Q

formation of Lamelav bone and remodeling:

A

week 6-18

27
Q

what happen in Exudative. proliferative phase?

A

(primary stability)
- bleeding: coagulum formation
- Site become inflamed: mesenchymal_GF Secretion_granulation tissue
Angiogenesis

28
Q

what happen at reticular bone phase (after week 2- 6)

A
  • Mesenchymal:
    fibroblast
    osteoblast
    osteoclast
29
Q

what happen at lamellar bone phase?

A

Secondary stabilization

mineralization increases_vascularization (woven bone)

30
Q

osteo conduction definition? limp I

A

the process in which the graft (Autograft- Allograft-
✗ enogivaft - alto plastic) creats a scaffold matrix to support
bone attach and grow unit.

31
Q

osteo conduction def? (summitry)

A
  • deposition + New bone formation
32
Q

(?) is important and crucial for vessel ingrowth and bone
matrix deposition. and should be similar to normal bone as possible.

A
  • proper structure and design (scaffold)
33
Q

allograft?

A
  • processed humman bone (from one person to another)
34
Q

Autogenous bone graft?

A
  • Patient own tissue.
35
Q

Xeno graft?

A

HA-Natural
(Bio-OSS)
from one species to another

36
Q

previous + here = material used.
- synthetic poly ters
- tri calcium phosphate
- Bio glass ceramic

A
37
Q

osteo induction def

A

a process which include stem cells, differentiation
into osteogenic cells in order to form bone by growth factor

38
Q

material used in 01 phase:

A
  • demin bone matrix
  • bone morphogenic matrix protein
  • Growth factor injection
  • Gene therapy (from Auto. or Allograft)
39
Q

Growth factor acts on (?) and osteoblasts?

A
  1. = Fibroblast.
40
Q

osteogenesis definition?

A

process providing stem cells with osteogenic potential
which Lays down new bone.

41
Q

material use in osteogenesis?

A

ONLY autogenous bone grafts.

42
Q

N) combined process is?

A

كلاس ٣ (5 decks)

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