Topic 13 Flashcards
Pure Food and Drug Act
This law simply requires all medications to be free of impure products.
Food and Drug Administration (FDA)
a federal agency that enforces medication laws to ensure that all medications on the market undergo vigorous testing before they are sold to the public.
MedWatch Program
This voluntary program encourages nurses and other health care professionals to use the MedWatch form to report when a medication, product, or medical event causes serious harm to a patient.
chemical medication name
provides the exact description of medication’s composition
ex: N-acetyl-para-aminophenol
generic medication name
the manufacturer who first develops the drug assigns the name, and it is then listed in the U.S. Pharmacopeia
ex: acetaminophen
trade medication name
also known as brand or proprietary name. This is the name under which a manufacturer markets the medication.
ex: tylenol
Pharmacokinetics
the study of drug movement throughout the body
Four processes of pharmacokinetics
absorption, distribution, metabolism, excretion
For medications to be therapeutic, they must be…
taken into a patient’s body; be absorbed and distributed to cells, tissues, or a specific organ; and alter physiological functions.
absorption
Passage of medication molecules into the blood from the site of administration
Factors that influence absorption
- Route of administration
- Ability of the medication to dissolve
- Blood flow to the site of administration
- Body surface area
- Lipid solubility
absorption of applying medication to the skin and through the GI is usually..
slow
what medication administration has the fastest absorption rate
IV
The richer the blood supply to the site of administration, the…
faster a medication is absorbed.
distrubution
occurs within the body to carry medication to tissues, organs, and specific sites of action.
distribution depends on
Physical and chemical properties of the medication
Physiology of the person taking it
-Circulation
-Membrane permeability
-Protein binding
Metabolism (biotransformation)
The biochemical process that alters a drug from an active form to a form that is inactive or that can be eliminated from the body.
excretion
the process by which wastes are removed from the body
medications exit the body through…
kidney, liver, bowel, lungs, exocrine glands
what is the main organ for excretion
kidneys
Which type of medications are excreted through the lungs?
Anesthetic gases, alcohol
Why should certain medications not be taken during pregnancy?
Some may pass through the placental barrier or mammary glands.
Biotransformation happens where?
liver
The exocrine glands excrete
lipid soluble medications
therapeutic effect
Expected or predicted physiological response
adverse effect
Unintended, undesirable, often unpredictable
side effect
Predictable, unavoidable secondary effect
toxic effect
Accumulation of medication in the bloodstream
idiosyncratic reaction
Over-reaction or under-reaction or different reaction from normal
allergic reaction
unpredictable response to a medication
medication interaction
When a medication may modify or diminish the actions of another medication
synergistic effect
interaction of two or more medicines that results in a greater effect than when the medicines are taken alone
minimum effective concentration (MEC)
The smallest amount of drug necessary in the blood or target tissue to result in a measurable intended action.
toxic concentration
the plasma level at which toxic effects begin
therapeutic range
that concentration of drug in the blood serum that produces the desired effect without causing toxicity
-falls between the MEC and the toxic concentration
Peak
highest effective concentration
Trough
minimum blood serum concentration of medication reached just before the next scheduled dose
biological half-life
which is the time it takes for excretion processes to lower the amount of unchanged medication by half
To maintain a therapeutic plateau the patient must…
receive regular fixed doses
Time-critical medications
medications in which early or delayed administration of maintenance doses (more than 30 minutes before or after the scheduled dose) will most likely result in harm or subtherapeutic responses in a patient
when do you administer time critical medications
at a precise time or within 30 minutes before or after the scheduled time
when do you administer non- time critical medications
within 1 to 2 hours of their scheduled time
Sublingual administration
drugs are given by placement under the tongue
sublingual instructions
Instruct patients not to swallow a medication given by the sublingual route or drink anything until the medication is completely dissolved to ensure that the medication will have the desired effect
Buccal administration
placing the solid medication in the mouth against the mucous membranes of the cheek until it dissolves
buccal instructions
Teach patients to alternate cheeks with each subsequent dose to avoid mucosal irritation. Warn patients not to chew or swallow the medication or to take any liquids with it
what route is the easiest and the most commonly used route of medication administration
oral route
4 major parenteral routes of administration
intradermal, subcutaneous, intramuscular, intravenous
Intradermal (ID)
Injection into the dermis just under the epidermis
Subcutaneous
Injection into tissues just below the dermis of the skin
Intramuscular (IM)
Injection into a muscle
IV
Injection into a vein
Nurses administer inhaled medications through
asal passages, oral passages, an endotracheal tube, or a tracheostomy tube
topical administration
administration of a substance directly onto the skin or mucous membrane (generally have local effects)
Intraocular medication
delivery involves inserting a medication similar to a contact lens into a patient’s eye. The eye medication disk has two soft outer layers that have medication enclosed in them. The nurse inserts the disk into the patient’s eye, much like a contact lens. The medication remains in the eye for up to 1 week.
solution
a given mass of solid substance dissolved in a known volume of fluid, or as a given volume of liquid dissolved in a known volume of another fluid.
-When a solid is dissolved in a fluid, the concentration is in units of mass per units of volume (e.g., g/L, mg/mL).
health care providers role in medicaton administration
*Prescriber can be physician, nurse practitioner, or physician’s assistant.
*Orders can be written (hand or electronic), verbal, or given by telephone.
*The use of abbreviations can cause errors; use caution.
computerized physician order entry (CPOE)
In using this system, the prescriber completes all computerized fields before the order for the medication is filled, thus avoiding incomplete or illegible orders.
Standing or routine order
Administered until the dosage is changed or another medication is prescribed
PRN, prn
as needed; given when the patient requires it
single (one-time)
given one time only for a specific reason