TOPIC 10 Flashcards

1
Q
  • can cause fluid loss through
    urination, thus decreasing blood volume
    and lowering blood pressure.

-Before giving monitor bp & hr

A

DIURETICS

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2
Q
  1. Corticosteroids
  2. oral contraceptives
  3. estrogen
  4. erythropoiesis
  5. sibutramine
A

DRUDS ASS W/ HTN

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3
Q
  1. Cushing syndrome
  2. hyperthyroidism
  3. chronic renal impairment
  4. pheochromocytoma
  5. arteriosclerosis
A

Diseases associated with elevated BP

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4
Q
  • First line drugs for hypertension because the produce few adverse effects and are very effective at controlling mild to moderate hypertension
A

Diuretics

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5
Q
  • Widely used in the treatment of hypertension and heart failure
A

Diuretics

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6
Q

most commonly used diuretic

A

Furosemide lasix

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7
Q
  • Has been the mainstay for the pharmacotherapy of hypertension for a decade
A

Thiazide & like drugs

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8
Q
  • Most prescribed diuretics for hypertension.
  • Produces few adverse effects and is effective at producing a 10-20 mm Hg reduction in blood pressure
A

HYDROCHLOROTHIAZIDE (hydroDIURIL)

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9
Q
  • Are inexpensive and most are available in generic formulations
  • Safe drugs, with urinary potassium loss being the primary adverse effects hence monito K level
A

Thiazide

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10
Q
  • Beneficial when clients are at risk of developing hypokalemia owing to their medical condition or to the used of thiazide or loop diuretics
  • Produce only a modest diuresis
A

Potassium Sparring Diuretics

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11
Q
  • Cause more diuresis and thus greater reduction in blood pressure, than the thiazide or potassium sparing diuretics
  • Are not ideal agents for HTN maintenance therapy.
  • Often reserved for more serious cases of hypertension
A

Loop diuretics

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12
Q

most commonly used k sparring diuretic

A

spironolactone (aldactone)

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13
Q

widespread use loop diuretics; prototype for heart failure

A

Furosemide (lasix)

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14
Q

used to treat angina pectoris, dysrythmias, and HTN

A

CCB

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15
Q

first approved in the treatment of ANGINA in 1980

A

CCB

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16
Q
  • not used as monotherapy for htn
  • promotes vasodilation
A

CBB

17
Q

for mild to moderate HTN: CCB

A

AMLODIPINE (Norvasc)

18
Q

stage 1 and 2, HTN, and ANGINA : CCB

A

FELODIPINE (plendil)

19
Q

for essential HTN: CCB

A

NICARDIPINE ( cardene)

20
Q

Are selective for calcium channels in arterioles

A

Nifedipine (Procardia)

21
Q

Generally prescribed for HTN and variant or vasospastic angina

A

Nifedipine (Procardia)

22
Q

Acts by selectively blocking calcium channel in myocardial and vascular smooth muscle

A

Nifedipine (Procardia)

23
Q

Affect channels in both arterioles and the myocardium

A

Verapamil (Calan)

24
Q
  • For HTN, and angina pectoris
  • Is featured as a prototype antidysrhythmic
A

Verapamil (Calan)

25
Q

For antianginal

A

Diltiazem (Cardizem)

26
Q

Flushed skin
headache
dizziness
Peripheral edema, edema
lightheadedness
Nausea and diarrhea

A

ADVERSE EFFECTS OF CCB FOR HTN

27
Q

Hepatotoxicity
MI
Confusion
Mood changes

A

SERIOUS ADVERSE EFFECT OF CCB

28
Q

Heart rate increases owing to the rapid fall in blood pressure created by the drug CCBs

A

REFLEX TACHYCARDIA

29
Q

CCB contraindication

A
  1. Sinus sick syndrome
  2. 3rd degree AV block w/o pace maker
30
Q

key homeostatic mechanism controlling blood pressure and fluid balance

A

Renin angiotensin system

31
Q

Is approved to treat hypertension since 1980

A

Angiotensin Converting Enzyme (ACE)

32
Q
  • Key agents in the treatment of HTN
  • block the effects of angiotensin Il, decreasing the blood pressure through two mechanisms:
    1. lowering peripheral resistance
    2. decreasing blood volume.
A

ACE inhibitors

33
Q

Have become primary drugs for the treatment of heart failure and myocardial infarction.

A

ACE inhibitors

34
Q

Persistent cough and postural HTN
Hyperkalemia- major concern for diabetics
Headache
orthostatic hypotension
rash

A

SIDE EFFECTS OF ACE INHIBITORS

35
Q
  1. Development of angioedema- most often develop within hours or days after beginning ACE inhibitor therapy.
  2. Renal failure

*Angioedema & renal failure - first phenomenon

A

SERIOUS ADVERSE EFFECTS OF ACE INHIBITORS

36
Q

life-threatening effect of ACE inhibitors

A

angioedema and can cause asphyxia

37
Q
  1. paroxysm of dry cough
  2. stridor
A

symptoms of angioedema:

38
Q

ACE is contraindicated

A

pregnancy