topic 1 - sleep Flashcards
1
Q
adenisine action hypothesis
A
- homeostatic control of sleep
- disinhibts the VLPOA meaning your gonna go to sleep
- inhibits arousal areas by connecting to GABA-ergic synapses
2
Q
k complex
A
if theres a peak - in stage 2 sleep
3
Q
sleep spindles
A
fast burst of activity and occurs in all stages of sleep
4
Q
where is seratonin from
A
raphe nuclei
5
Q
where is histamine from
A
tuberomammiraly necleus
6
Q
where is noreadrenaline from
A
locus coeruleus
7
Q
where is hypocretin from
A
lateral hypothalamus
8
Q
endogenous clock
A
- Bmall and clock form a protein complex in the nucleus
- they act as a transcription factor for period 1,2, 3 & chrymptochromes
- chrymptochrome, period 1 &3 form a protein complex and chryptochrome& period 1 form a protein complex. which then inhibit Bmall & Clock
- Cry & Per3 also form a protein complex
- Delay until Cry, Per1 & 3 then inhibit Bmall & clock
- Another delay until Cry & Per3 then act as a transcription factor for Bmall and Clock
- cycle starts again
9
Q
Allostatic control
A
- moderated by stress or hunger
- ghrelin is when hungry and promotes hypocretin
- Leptin when full - inhibits hypocretin
10
Q
homeostatic control
A
- adenosine produced which leads to a build up due to brain activity therefore need to recovery
- induces sleep through disinhibition of the vLPOA which inhibits areas associated with wakefulness
11
Q
Circadian control
A
- endogenous clock
