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1
Q

puberty and hormones

A
  • high activity in GABA/NPY nuerons means puberty hasn’t started
  • Inhibition of GABA activates release of KNDy and GnRH
  • enters the pituitary gland - anterior part detects this and releases LH and FSH (gonadotropins)
  • post pituitary gland then releases vasopressin and oxytocin
  • gonadotropins travel to gonads where testosterone is released in response to LH in males (FSH triggers sperm production)
  • forms a negative feedback system: binds to receptors in hypothalamus, inhibiting the release of GnRH and in the anterior pituitary gland gonadotropins are inhibited.
  • In females FSH stimulates the follicle to ripen and LH induces ovulation.
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2
Q

sexual arousal

A
  • testesterone levels in men and women when sex and oestradiol determines sexual motivation in women.
  • pheromones - picked up by the nose
  • type of pheromones: androstadienone which is mens sweat and estratetrene in womens urine which causes activation in hypothalamus in women
  • info is integrated and excites the parasympathetic nervous system which excites preganglionic neuron which releases acetylcholine which binds onto nicotine on a post ganglionic neuron which again releases acetylcholine into muscles
  • causing blood vessels relax allowing more blood to enter causing erection
  • sympathetic nervous system joins in the same way (acetylcholine release) when orgasm is approached but also releases noradrenaline.
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3
Q

pain and pain suppression

A
  • Somatosensory pathways:
  • the descending analgesic pathway begins with damaged cells producing cytokines including prostaglandis which respond to inflammation
  • incomming nociceptor creates a cell body in the dorsal horn of the spinal cord and create a synapse.
  • Glutamate is the main neurotransmitter and substance-P as a co-transmitter (amplifier)
  • the axon of that neuron runs through the other side of the spinal cord, through medulla and mid brain and makes a synapse in the thalamus.
  • neurons from thalamus make synapses onto neurons in the primary somatosensory cortex which tells us where the pain is
  • if message doesn’t reach brain - not pain
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