Topic 1: Lifestyle, Health and Risk Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

1.1) Why do organisms need mass transport systems?

A

1) organisms need to be constantly exchanging substances with their environment in order for their cells to carry out important metabolic processes and remove harmful waste products.

2) Most multicellular organisms need a mass transport systems because the bigger an organism is, the lower its surface area to volume ratio and the larger the diffusion distance is to its cells. This decreases the rate of diffusion of substances into and out of the cells.

3) As a result mass transport systems are needed to ensure a sufficient supply and removal of substances to and from the organisms cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

1.2) What is meant by a dipolar molecule?

A

A dipolar molecule is a molecule that has a partial negative charge on one side and a partial positive charge on the other caused by an uneven distribution of electrons.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

1.2) What makes water good at transporting substances?

A

Water’s dipole nature makes it both cohesive and a good solvent.
- Cohesion is the attraction between molecules of the same type. Water molecules are very cohesive because they’re dipolar. This helps water flow, making it great for transporting substances.
-water is also able to hydrogen bond to other molecules; this is known as adhesion. This means water flows easily.
-Water’s dipole nature makes it useful as a solvent in living organisms because it dissolves ionic substances. E.g. in humans, important ions can dissolve in the water in blood and then be transported around the body.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

1.3)How does the structure of a artery relate the its function?

A

Arteries transport oxygenated blood away from the heart

  • Outer Wall: Contains elastic tissue, which helps to maintain blood pressure in the arteries. It stretches and recoils to even out any fluctuations in pressure. Contains the structural protein collagen. Collagen is a strong protein that protects blood vessels from damage by over-stretching.
  • Endothelium: Very smooth and reduces friction for free blood flow. Its highly folded, enabling it to expand under high pressure.
  • Thick inner layer of muscle and elastic fibres: Muscle cells strengthen the arteries so that they can withstand high pressure. Contraction of the muscles also enables the blood vessel to constrict and narrow the lumen for reduced blood flow (i.e. for the redirection of blood flow during exercise).

-Narrow Lumen: Helps to maintain a high blood pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

1.3) How does the structure of a vein relate to its function?

A

Transports deoxygenated blood back to the heart.

  • Thin muscle wall: There is no need for a thick muscular layer as veins don’t have to withstand high pressure .
  • Wide Lumen: Helps to ensure that blood returns to the heart at an adequate speed and increases the volume of blood that can be delivered per unit of time. It also reduces friction between the blood and the endothelium layer of the vein.
  • Contains valves: Prevents backflow of blood helping return blood to the heart.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

1.3) Capillary Beds

A

Networks of capillaries (small bloods vessels) that allow the exchange of gas, water and nutrients.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

1.3) How does the structure of capillaries relate them to their function?

A

Capillaries exhange materials between the blood and tissue cells.

  • The capillary wall is made of a single layer of flattened endothelial cells. The wall is 1 cell thick; this reduces the diffusion distance for oxygen and co2 between the blood and the tissues of the body.
  • Narrow Lumen: Red blood cells need to pass through the capillaries single file. This forces the blood to travel slowly which provides more time for diffusion to occur.
  • Pores in the walls: The cells of the wall have gaps called pores which allow for the exchange of larger molecules. They allow blood plasma to leak out and form tissue fluid. White blood cells can combat infection in affected tissues by squeezing through the pores in capillary walls.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

1.12) monosaccharides

A

Monosaccharide are single sugar monomers. They are the simplest carbohydrates.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

1.12) Disaccharides

A

Disaccharides are formed by joining two monosaccharides together in a condensation reaction.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

1.12) polysaccharides

A

Polysaccharides are carbohydrate polymers made up of many monosachccharides joined by glycosidic bonds in a condensation reaction to from chains.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the name of the bond that is formed when monosaccharides join together?

A

Glycosidic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

1.12) What is the name of the reaction that joins monosaccharides together?

A

Monosaccharides join together via a condensation reaction. This forms water and creates a glycosylic bond.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

1.12) What is the name of the reaction that breaks monosaccharides apart?

A

Monosaccharides are broken apart via a hydrolysis reaction. This requires water and breaks a glycosydic bond.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

1.12) What is the main energy store in plants?

A

Starch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What makes starch good for storage?

A

It is insoluble in water so it doesn’t cause water to enter cells by osmosis which would make them swell. This makes it good for storage.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

1.12) Starch is a mixture of what two polysaccharides?

A

Amylose and Amylopectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

1.12) Amylose structure

A

-Unbranched chain of a-glucose.
-Joined by 1-4 glycosidic bonds.
-Coiled structure makes it compact and good for storage.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

1.12) Amylopectin structure

A

-Branched chain of glucose (side branches allow enzymes to get to the glycosidic bonds easily so glucose can be released quickly).
-Contains 1-4 and 1-6 glycosidic bonds.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

1.12) What is the main energy store in animals?

A

Glycogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

1.12) Describe the structure of Glycogen and how it is adapted to it’s role as an energy store in animals.

A
  • Glycogen is a polysaccharide of a-glucose
    -Its structure is similar to amylopectin (it has 1-4 and 1-6 glycosidic bonds), except it has even more side branches.
    -lots of branches means that stored glucose can be released quickly, which is important for energy release in animals.
    -It is a large molecule so stores lots of energy.
    -It is a compact molecule so good for storage.
    -It is insoluble in water so doesn’t cause the cell to swell by osmosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the difference between a-glucose and B-glucose structurally?

A

The position of of the hydroxyl (-OH) group.
- in a-glucose the hydrogen is above the hydroxyl group.
- in b-glucose the hydrogen is below the hydroxyl group.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what is the molecular formula of glucose?

A

C6H12O6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is the function of glucose?

A

It is the main energy stource for animals and plants.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How is the structure of glucose related to its function?

A

-It is soluble so can be transported easily.
-It is small so is easily transported in and out of cells via carrier proteins.
-It has many covalent bonds which store energy.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What two monosaccharides combine to make the disaccharide maltose and what is the glycosidic bond that forms?

A

a-glucose and a-glucose join with a 1-4 glycosidic bond.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What is the function of maltose?

A

It is an energy source in germinating seeds.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What two monosaccharide join to form the disaccharide sucrose and what is the glycosidic bond that forms?

A

a-glucose and fructose join with a 1-2 glycosidic bond.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What is the function of sucrose?

A

Sucrose is transported in the phloem to provide sugars to other parts of the plant.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What two monosaccharides combine to form the disaccharide lactose and what is the glycosidic bond that forms?

A

b-glucose and galactose join with a 1-4 glycosidic bond

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What is the function of lactose?

A

Lactose is found in mammalian milk to provide energy for infant mammals .

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What does a triglyceride consist of?

A

One glycerol molecule and three fatty acids.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Explain the formation of a triglyceride.

A

The hydrogen atoms from the hydroxyl groups on the glycerol molecule bond to a hydroxyl group (OH) on each fatty acid. This forms 3 ester bonds between the glycerol molecule and each fatty acid. The process releases 3 molecules of water so it is an example of a condensation reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What is the structure of a fatty acid?

A

A fatty acid consists of a carboxylic group and a long hydrocarbon tail.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Saturated lipids

A

Saturated fatty acids contain only single covalent bonds between the carbon atoms.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Unsaturated lipids

A

Unsaturated fatty acids have at least one double covalent bond between the carbon atoms.

36
Q

What makes lipids insoluble in water?

A

-Fatty acid tails are hydrophobic (water-repelling)
-These tails make lipids insoluble in water.

37
Q

What are the stages of the cardiac cycle?

A

1) Atrial systole (ventricular diastole)
2) ventricular systole (atrial diastole)
3)Cardiac Diastole

38
Q

Atrial Systole

A

-The ventricles both relax.
-Blood flows into the atria, via the vena cava and pulmonary veins.
-As the atria fills, the pressure increases.
-The atria then contract, decreasing their volume, more blood flows into the ventricles.

39
Q

Ventricular Systole

A

After a SHORT delay:
-The atria relax.
-The ventricles contract, decreasing their volume and increasing the pressure.
-Higher pressure in the ventricles than in the atria, cause the AV valves to shut (‘lub’), stopping backflow in the atria.
-The higher pressure causes the semi lunar valves to open and blood is forced into the pulmonary artery and the aorta.

40
Q

Cardiac Diastole

A

-The ventricles and the atria both relax.
-Increasing the volume and lowering the pressure in the heart (due to elastic recoil).
-The higher pressure in the pulmonary artery and the aorta closes the semi lunar valves (‘dub’)
-The atria then fill with blood again due to higher pressure in the vena cava and pulmonary vein. This forces the AV valves to open and the cycle starts again.

41
Q

List the parts of the heart

A

-Right atrium
-Left atrium
-Right ventricle
-Left ventricle
-coronary artery
-superior vena cava
-inferior vena cava
-pulmonary artery
-pulmonary veins
-aorta
semi-lunar valves
-atrioventricular valves
-cords (valve tendon)

42
Q

How is the structure on the ventricles related to their functions?

A

-The ventricles have thicker muscular walls than the atria, because they have to push blood out of the heart whereas atria just need to push blood a short distance into the ventricles.
-The left ventricle has thicker, more muscular walls than the right ventricle, because it needs to contract powerfully to pump blood all the way around the body. The right side only needs to get blood to the lungs, which are nearby.

43
Q

How can the relationship between heart structure and function be investigated practically?

A

via a heart dissection:

Through an external examination you will be able see the major vessels and feel that the arteries are thick and rubbery, whereas veins are much thinner.

Through and internal examination, using a scalpel, you should be able to see that the ventricles walls are thicker than the atria walls and that the left ventricle walls are thicker than the right ventricle walls.

44
Q

Why does the heart contain valves?

A

-The atrioventricular (AV) link the atria to the ventricles to stop blood flowing back into the atria when the ventricles contract. Cords (valve tendons) attach the AV valves to the ventricles to stop them being forced into the atria when the ventricles contract.

-The semi-lunar valves link the ventricles to the pulmonary artery and aorta, and stop blood flowing back into the heart after the ventricles contract.

45
Q

Carbohydrate

A
  • A carbohydrate is a biomolecule consisting of carbon, hydrogen and oxygen atoms.
  • A carbohydrate is an organic compounds such as sugar or startch and is used to store energy.
46
Q

What is atherosclerosis?

A

Atherosclerosis is the process by which atheroma plaques form in the endothelium of the arteries.

47
Q

1.5) Stages of atherosclerosis

A

Stage 1: ENDOTHELIUAL DYSFUNCTION - Damage, e.g. by high blood pressure, is caused to the endothelium.
Stage 2: the damage to the endothelium causes INFLAMMATORY RESPONSE. This is where while blood cells (mostly macrophages) move into the damaged area.
Stage 3: WHITE BLOOD CELLS ABSORB SATURATED FATS AND CHOLESTEROL from circulating LDLs. The white blood cells and fats clump together under the endothelium to form FATTY STREAKS.
Stage 4: Over time, more white blood cells, lipids (fats) and connective tissue build up to form a fibrous PLAQUE called an ATHEROMA. The atheroma narrows the lumen of the artery, reducing and restricting blood flow and thereby RAISING BLOOD PRESSURE.
stage 5: Over time the plaque can CALCIFY AND HARDEN, reducing elasticity of the artery wall and further increasing blood pressure.

  • Artery walls can burst open due to damage caused by atheromas. Platelets then accumulate and form a clot called a thrombus.
48
Q

What is the name of the process used by the body to prevent blood being lost when a blood vessel is damaged?

A

Thrombosis (blood clotting)

49
Q

1.6) Describe the blood clotting process

A

1) A protein called thromboplastin is released from the damaged blood vessel.
2) Thromboplastin, along with calcium ions from the plasma, triggers the conversion of prothrombin (a soluble protein) into thrombin (an enzyme).
3) Thrombin then catalyses the conversion of fibrinogen (a soluble protein) to fibrin (solid insoluble fibres).
4) The fibrin fibres tangle together and form a mesh in which platelets (small fragments of cells in the blood) and red blood cells get trapped - this forms the blood clot.

50
Q

Cardiovascular Disease (CVD)

A

A general term for a disease of the heart or blood vessels.

51
Q

1.6) How does an atheroma increase the risk of blood clotting?

A
  • The plaque deposit of an atheroma can rupture through the endothelium
  • platelets stick to the ruptured area
  • This triggers the process of thrombosis
52
Q

1.6) What can blooding clotting lead to?

A
  • Heart attacks
  • Deep vein thrombosis
  • Strokes
53
Q

1.6) Coronary Heart disease (CHD)

A

1) Coronary heart disease is caused by the formation of atheroma’s and blood clots in the coronary arteries.
2) Blood flow to certain areas of the heart is restricted and delivery of oxygen to the affected cells decreases, thereby reduces respiration to these cells.
3) Cells no longer produce ATP, can no longer contract, reducing the force generated by the heart. Cells can die causing permanent damage to the heart tissue.
4) This leads to myocardial infarctions (heart attack) or can cause complete heart failure.

54
Q

1.6) Ischemic stroke

A
  • A stroke is a sudden loss of brain function in a localised area due to disruption of blood flow to the brain. (an ischemic stroke is caused by blood clots).
  • 1) A blood clot leads to a blockage of the arteries supplying the brain.
    2) This leads to reduced blood flow and delivery of oxygen to the cells of the brain, reducing respiration.
    3) Cells in the affected part of the brain cannot produce ATP and their function in reduced.
55
Q

1.6) Deep vein thrombosis

A
  • When a blood clot forms in a vein deep inside the body (most common in the veins of legs).
  • causes include: prolonged inactivity, old age, some medications.
56
Q

1.7) Explain the lifestyle factors linked to CVD

A
  • Diet - A diet high in saturated fat increases blood cholesterol levels, increasing atheroma formation and therefore thrombosis. A diet high in salt increases blood pressure.
  • High blood pressure - Increases risk of damage to the artery walls, which increases the risk of atheroma formation and therefore thrombosis. Excessive alcohol consumption, stress, inactivity and poor diet can increase blood pressure.
  • Smoking - Carbon monoxide in cigarette smoke combines with haemoglobin (the protein that carries oxygen in the blood) and reduces the amount of oxygen transported in the blood. This decreases respiration in the cells of the brain and heart which can lead to stroke and heart attack. Nicotine makes platelets sticky, increasing the chance of blood clots forming, which increasing the risk of CVD. Smoking also decreases the amount of antioxidants in the blood, which are important for protecting the cells from damage. Fewer antioxidants means cell damage in the artery wall in more likely, and this can lead to atheroma formation and therefore thrombosis.
57
Q

1.7) What other factors (not related to lifestyle) are linked to CVD

A
  • Genetics - Individuals can inherit alleles making them more prone to high blood pressure or high cholesterol, therefore more likely to develop CVD.
  • Age - The risk of developing CVD increases with age due to blood vessels becoming more fragile and plaque building up over time.
  • Biological sex - Men are 3x more likely to suffer from CVD than pre-menopausal women, most likely due to the lower level of oestrogen. Oestrogen, which is typically higher in females, increases levels of ‘good’ cholesterol (HDL).
58
Q

Describe how monosaccharides are joined to form disaccharides

A

-OH groups from neighbouring monosaccharides undergo a condensation reaction to form a glycosidic bond - an O- link - between the two monosaccharides, with water being released.

59
Q

1.8) What’s the different between correlation and causation?

A

Correlation is where a change in one variable occurs AT THE SAME TIME as a change in another variable.
Causation is where the change in one variable CAUSES the change in another.
Just because two factors correlate it does not mean that one causes the other.

60
Q

1.8) Describing data

A
  • Identify trends (i.e. as age increases the relative risk of CVD increase.)
  • State what the results show (i.e. the oldest age group has the highest risk of CVD)
  • Use numbers for the data to back up description
61
Q

1.8) Drawing conclusion from data

A
  • working out what the data shows about the RELATIONSHIP BETWEEN VARIABLES.
    e.g. the data shows that there is an ASSOCIATION or a CORRELATION, between ages and the relative risk of heart disease.
  • Conclusions should always be limited to what the data show. Causal relationships cannot be concluded from one data set. conclusions cannot be extrapolated beyond the setting of the study.
62
Q

Evaluating the validity of data

A
  • Larger sample sizes are more likely to give valid results as is likely more representative of target population.
  • control study for comparison
  • Reliability - studies should be repeated
  • Validity - Extraneous variables should be controlled
  • Researcher should not be biased
63
Q

Conflicting evidence

A
  • Conflicting evidence is that which shows a different pattern to the evidence gained elsewhere.
  • When conflicting evidence arises, more research is needed to show which pattern is correct.
  • Conflicting evidence is often a sign that other variables are involved.
64
Q

Evaluating experimental design

A
  • The sample (larger samples = more representative, random selection reduces bias)
  • Variables (the more variables that have been controlled the more reliable and valid the data)
  • Reliable (reproducible experiment + repeated data)
  • valid (only tested one IV)
  • Data (bias can come from human sources, e.g. selecting a non-random sample or manipulating data)
  • Controls - experimental controls for comparison
65
Q

Perception of Risk

A

Risk is defined as the chance or probability that a harmful event will occur.
An individual’s perception of risk may be different to the actual risk of something occurring:
Risks can be overestimated because of factors such as:
- Misleading info in media
- Overexposure to info
- personal experience of the associated risk
- The event causing severe harm

Risks can be underestimated because of factors such as:
- Lack of info
- Misunderstanding of factors that increase risk
- Lack of personal experience of associated risk
- Unfamiliarity with event
- Harm being non-immediate

66
Q

Energy budget

A

The term energy budget describes the amount of energy taken in by an organism minus the amount of energy the organism transfers during life processes such as growth, movement, reproduction, and respiration.
Energy input - energy output = energy budget

67
Q

Analysing data on energy budgets:
- Ranjit takes in the recommended daily intake of calories a day (2500). He swims for one hour and does one hour of gardening each day. He also cooks for an hour each day. His bodily functions (e.g. breathing) use up 1500 calories per day. Using the information bellow, work out Ranjit’s energy budget.

Activity—————–Number of calories
———————————used per hour
Cooking————–159
Dog walking———224
Gardening———–328
Swimming———–513

A

Step 1: You need to multiply the number of calories per hour by the number of hours each activity lasts:
513 x 1 = 513
328 x 1 = 328
159 x 1 = 159
1500

Step 2: Energy Input - Energy Output
2500 - (1500 + 513 + 328 + 159) = 0

Ranjit’s energy budget is balanced - he takes in as much as he uses up.

68
Q

Christina takes in 2000 calories a day. She walks the dog for an hour every morning and every night. Her bodily functions use up 1200 calories per day. Work out her energy budget using the information below:

Activity—————-Number of calories
————————–used per hour
Cooking————–159
Dog walking——–224
Gardening ———-328
Swimming———–513

A

Step 1: You need to multiply the number of calories per hour by the number of hours each activity lasts:

224 x 2 = 448
1200

Step 2: Energy Input - Energy Output
2000 - 448 = **352 calories **

Christina has an excess of 352 Calories per day

69
Q
  • A student’s recommended daily intake of energy is 12,400KJ.
  • Mark is a male student who takes in the recommended daily intake of energy; he is in school for 6 hours a day, goes for a run for 1 hour after school, sleeps for 8 hours a night, and spends 2 hours a day eating meals.
    Use the info bellow to calculate his energy budget over a 24 hour period:

Activity—————–Energy expenditure /
—————————KJmin-1
Walking—————6
Learning ————-4
Running————–17
Eating Meals——–5
Sleeping————–3

A

Step 1: Convert the values into the number of hours the student spend on each activity:
School = (4 x 60) x 6 = 1440KJ in 6hrs
Running = 17x60 = 1020KJ in 1 hr
Sleep = (3 x 60) x 8 = 1440 KJ in 8 hrs
meals = (5 x 60) x 2 = 600KJ in 2 hrs

Step 2: Add up the energy expenditures to find the energy output:
1440 + 1020 + 1440 + 600 = 4500 KJ

Step 4: Substitute numbers into the energy budget equation:
Energy input - energy output = energy budget
12, 4000 - 4500 = 7,900 KJ

This tells us that the student has an excess of 7,900KJ of energy every day.

70
Q

Energy Imbalance

A

Energy imbalance causes changes in weight .

Weight Gain:
- If energy intake is higher than energy output, the excess energy will be turned into fat reserves by the body so the person will gain weight.
- If the energy difference is a lot and it’s sustained over a long period of time, the person could become obese.

Weight Loss:
- If energy intake is lower than energy output (energy deficit), the body will have to get more energy from somewhere - it’ll turn some of it’s fat reserves into energy, so the person will lose weight.
- If this energy difference is large and sustained over a long period of time, the person is likely to become underweight.

71
Q

Evaluating data linked to risk factors

A

consider:
- Sample size
- Individuals in the sample
- Control group
- Statistical significance (if standard deviations overlap then the difference between data sets is not statistically significant).

Exam tip: when dealing with data include numbers, remember correlation not causation and look for cues about validity of the experiment.

72
Q

cholesterol

A

Cholesterol is a type of lipid produced in the body. Cells require a sourced of cholesterol for cell membrane functioning, sex hormone structure, and the synthesis of bile. Cholesterol is transported around the body as lipoproteins.

73
Q

Lipoproteins

A

Substances composed of both protein and lipid. There are two types of Lipoprotein: HDLs and LDLs.

74
Q

High density lipoproteins (HDLs)

A
  • Contain unsaturated fat, cholesterol and protein.
  • They are mainly protein
  • They transport cholesterol from body tissues to the liver where it’s recycled or excreted.
  • Their function is to reduce total blood cholesterol when the level is too high
75
Q

Low density lipoproteins (LDLs)

A
  • Contain saturated fat, cholesterol and protein.
  • They are mainly lipid.
  • They transport cholesterol from the liver to the blood, where it circulates until needed by cells.
  • Their function is to increase total blood cholesterol when the level is too low.
76
Q

Evidence linking blood cholesterol to CVD

A
  • medical treatments such as statins, which reduce blood cholesterol levels, also reduce risk of heart disease.
  • Diets high in saturated fats, which tends to cause high LDL cholesterol levels in the blood, have been linked to CVD events.
  • A significant reduction in total blood cholesterol levels is linked to as decrease in majority coronary events.
  • Arterial plaque regression has been observed alongside blood lipid-lowering therapy, which has led to a reduction in major cardiovascular events.
77
Q

Lifestyle advice to reduce the risk of CVD biased on scientific evidence

A

1) Diet: Scientific research has linked diets high in saturated fats to increased risk of CVD. This info can be used to educate people on their diets and SF intake. Food labels are encouraged to help people make informed choices about their diets. Scientific studies have shown obese people are more likely to develop CVD. Obesity indicators such as waist-to-hip ratio and BMI can be used to assess if someone is overweight or obese, and then that person can make choices to reduce their weight and reduce their risk of CVD, they can also monitor these changes.

2) Smoking: Scientific research has linked smoking to increased risk of CVD. This has led to TV adverts, warnings on cigarette packets and free advice + prescribed nicotine patches from the NHS.

3) Exercise: Scientific research has linked inactivity to increased risk of CVD. This research has led to campaigns that encourage more frequent exercise.

78
Q

A person’s hip measurement is 95cm and their waist measurement is 76cm. They are 1.68m tall and they have a BMI of 18.9kgm^-2
a) Use the formula shown bellow to calculate the person’s waist-to-hip ration.
b) Use the formula shown below to calculate the person’s body mass.

waist-to-hip ratio = waist (cm)/hips(cm)

BMI = body mass (kg) / height^2 (m^2)

A

a) waist-to-hip ratio = 76cm/95cm = 0.8

b) BMI + body mass (kg) / height ^2 (m^2)
body mass (kg) = BMI x height^2 (m2)
= 18.9 x 1.68^2
= 18.9 x 2.82
= 53.3kg

79
Q

Medication for CVD

A
  • Antihypertensive
  • statins
  • anticoagulants
  • platelet inhibitors
80
Q

Antihypertensives

A

Lowers blood pressure

Benefits:
- Reduce blood pressure
- The different types antihypertensive work in different ways, so they can be given in combination to reduce blood pressure.
- Blood pressure can be monitored at home, so the patient can see if the drugs are working.

Risks:
- Palpitations, abnormal heart rhythms, fainting, headaches and drowsiness are all side effects of these drugs caused by blood pressure becoming too low.
- Other side effects include allergic reactions and depressions

(examples: beta-blocketrs, vasodilators and diuretics)

81
Q

Statins

A

Reduce blood cholesterol levels

Benefits:
- Reduce the levels of ‘bad’ LDL cholesterol in the blood, so reducing the risk of atheroma development.
- Increase the levels of ‘good’ HDL cholesterol in the blood, which aids with further removal of LDL cholesterol.

Risks:
- Side effects include muscle and joint pain, digestive system problems and an increased risk of diabetes.
- Nosebleeds, headaches and nausea are also common side effects.
- Can take a while to become effective and need to be taken long-term to remain effective.
- may give false sense of security, leading to a return to an unhealthy lifestyle.

82
Q

Anticoagulants

A

Reduces the formation of blood clots as it affects the synthesis of clotting factors.

Benefits:
- Reduce the formation of new blood clots.
- Can reduce the size and growth of existing blood clots.

Risks:
- Can cause excessive bleeding if injury occurs, including internal injury.
- Side effects include allergic reactions, osteoporosis and swelling of the tissues
- Can damage the fetus if taken during pregnancy.

83
Q

Platelet inhibitory drugs

A

Reduce the formation of blood clots by reducing stickiness of platelets.

Benefits:
- Reduce the formation of new blood clots, and so the risk of blood vessel blockage.
- like anticoagulants, these can be used to treat people who already have blood clots or CVD.

Risks:
- Side effects include rashes, diarrhoea, nausea, liver function problems and excessive bleeding, especially after a serious injury.

84
Q

1.25) Vitamin C content of Juice

A

Variables:
- IV: Type of juice
- DV: Vitamin C concentration
- CV’s: Conc. and vol. of DCPIP, temp

Safety:
- Googles - avoid eye contact with acidic juices and DCPIP.
- Avoid skin contact with substances and wash immediately if contact is made.

Method:
1) Measure out 1cm cubed of DCPIP into a beaker.
2) Add juice to DCPIP (drop by drop) until it turns from blue to colourless.
3) Record volume needed
4) Repeat with the same juice (x3) and calc. mean.
5) Refer to calibration curve to find vit C concentration.
6) Repeat with other juices
7) Compare vit C conc. in the dif. juices (draw bar chart and SE bars)

85
Q

1.27) Caffeine on heart rate

A

Variables:
- IV: Concentration of caffeine solution (0-1%)
- DV: Heart Rate
- CV’S: Temp, size/species/age of daphnia, acclimatization time in solution.

Ethical Issues/suitability of daphnia:
- abundant
- Invertebrates with a simple N.S. (don’t feel pain)
- Transparent - can observe heart beating

Method:
Use a control = plain water
1) Use cotton wall to immobilize the daphnia onto a cavity slide.
2) Add the caffeine solution and leave to acclimatize for 5 mins.
3) Place under microscope, focus on the heart and count the heart beats in a certain time (by dotting paper or using a clicker). Then convert to bpm.
4) Repeat with the same caffeine conc. (X3)
5) Then repeat with different concentrations (0-1%)
6) calc. means
7) Plot a scatter graph and compare data

Conclusions:
No correlation between concentration of caffeine and heart rate.