Togaviruses & Flaviviruses Flashcards

1
Q

Structure

A

enveloped +ssRNA
Icosahedral capside
45-75 nm

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2
Q

Togaviruses

A

Alphaviruses (arthropod-spread encephalitis)

Rubivirus (rubella)

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3
Q

Flaviviruses

A

Alphaviruses (dengue, yellow fever, west nile, Zika, anthropod diseases.)
Hep C

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4
Q

pathogenesis

A

bite of an arthropod, e.g. mosquito. Lytic or persistent infections
FEMALE mosquitos. circulates in hosts plasma. infects endothelial cells of the capillaries + monocytes,macrophages dendritic cells

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5
Q

4 Phases + symptoms

A

Initial viremia - fever, chills, headaches, backaches, (flu-like) (most infections do not progress beyond here)
Secondary viremia - can infect target organs depending on tropism of virus
Brain infected - via endothilial cells lining vessels of brain
Hemorrhagic disease and shock - viral and immune cytolysis of infected vascular endothelial cells, + cytokine storm.

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6
Q

Immune response

A

IFN-a IFN-B
IgM for first week then IgG
immune response is important for resolution but exacerbates immunopathogenesis

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7
Q

Epidemiology

A

virus must stay wet, can be inactivated by drying,soap, detergents
Spread by arthropods

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8
Q

Control

A

Kill mosquitos
No treatments
Live attenuated vaccines

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9
Q

Diagnosis

A

RT-PCR for viral mRNA

monoclonal antibodies for distinguishing species/strains

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