Bunyavirus & Arenavirus Flashcards

1
Q

Bunyaviridae Group

A

SUPERGROUP! includes 200+ enveloped segmented ssRNA

most are arboviruses (arthropod)

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2
Q

Bunya Structure

A

spherical 90-120nm
envelope has 2 proteins G1 &G2
has 3 ssRNA

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3
Q

Bunya Pathogenesis

A

Viremia, secondary viremia, and target sites such as CNS, Liver, Kidney, vascular endothelium
Induce type 1 interferons

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4
Q

Bunya Symptoms

A

Usually mild nonspecific febrile, flulike, viremia related illness. fever ~ 3 days
Encephalitis illnesses
~1 week incubation, fever, headache, lethargy, vomiting,
Seizures, meningitis, <1% death.
Hemorrhagic fevers (rift valley fever)
Hantavirus: pulmonary syndrome. resp failure.

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5
Q

Bunya Diagnosis

A

RT-PCR on viral RNA

ELISA may detect antigen in clinical specimens with intense viremia

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6
Q

Bunya Control

A

no specific therapy.

kill mosquitos and rats(hantavirus)

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7
Q

Arenaviruses include:

A
Lymphocyte choriomeningitis(LCMV)
Hemorrhagic fever viruses: Lassa, Junin, Machupo.
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8
Q

Arena structure

A

enveloped virion, 2 circular ambi-ssRNA

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9
Q

Arena Pathogenesis

A

10-14 days
infect macrophages, induce cytokine + interferon. cell and vascular damage.
T cell immunopathies

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10
Q

Arena Epidemiology

A

Africa + South America
zoonosis via rodents
infect humans through: inhalation of aersols, contaminated food, fomites. (not usually bites)

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11
Q

Arena LCMV symptoms

A

Febrile + flulike myalgia
10% progress to CNS
perivascular mononuclear infiltrates

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12
Q

Arena Lassa and other hemorrhagic fevers symptoms

A
Fever(duh), coagulopathy, petechiae,
liver and spleen necrosis.
hemorrhage and shock.
occasional cardiac and liver damage. 
death in 50%
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13
Q

Diagnosis

A

RT-PCR for viral genome.
too dangerous for isolation
level3 for LCM
level 4 for Lassa + others

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14
Q

Treatment

A
Ribavirin (of course)
supportive therapy (so nothing really)
don't touch rats.
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15
Q

Immune response

A

requires CMI but antibody can help viremic spread.

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