Filoviruses

Question 1

Filoviruses?

Answer 1

Marburg and Ebola

Question 2

Filovirus structure?

Answer 2

filamentous, enveloped, -ssRNA

Question 3

Replication

Answer 3

binds: Niemann-Pick C1 (NPC1)
T-cell immunoglobulin and mucin domain 1 (TIM-1)
Replicates in cytoplasm

Question 4

Epidemiology

Answer 4

in Africa, rare cases outside africa.

Question 5

Ebola symptoms

Answer 5

Day 7-9: headache, fatigue, fever, muscle soreness
Day 10: sudden high fever, vomiting blood, passive behavious
Day 11: bruising, brain damage, bleeding from nose, mouth, eyes anus.
Day 12: internal bleeding, death

Question 6

Diagnosis

Answer 6

HANDLE WITH EXTREME CARE
requires level 4 isolation (not routinely available)
can be detected in tissue by IF, influids by ELISA, RT-PCR genome in secretions.

Question 7

treatment

Answer 7

antibody containing serum, artificial antibody, ribavirin.

infected patients quarantined. Contaminated animals sacrificed.