Togavirus

Question 1

Characteristics

Answer 1

RNA virus, positive sense strand, replicated in cytoplasm

Question 2

Family

Answer 2

Arbovirus (arthropod (e..g mosquitoes)-borne virus)

Rubella

Question 3

Arbovirus

Answer 3

Western, Eastern, and Venezuelan equine encephalitis

Question 4

Tx for arbovirus

Answer 4

No treatment for arbovirus

Question 5

Rubella characteristics

Answer 5

Aka German measles
Childhood exanthem
Contain envelope

Question 6

Rubella S&S: in childhood

Answer 6

Fatigue and fever

Causes post-auricular and cervical lymphadenopathy

Maculopapular rash (starts at the head and moves downward)- moves faster than measles and doesn’t darken or coalesce

Can be spread via respiratory droplets

Question 7

Rubella S&S: in adulthood

Answer 7

Lymphadenopathy, fever, arthralgias, and arthritis

Question 8

Rubella S&S: congenital

Answer 8

One of the ToRCHeS (+VZV and parvo)

Classic triad: Cataracts, sensorineural deafness, and PDA

Other common symptoms-
Mental retardation, microcephaly, Deafness, blindness, cataracts, jaundice, PDA, pulmonic stenosis, purpuric blueberry muffin rash, and radiolucent bone lesions

Question 9

Treatment

Answer 9

No treatment

Vaccine: MMR vaccine (live attenuated)- contraindicated for pregnant and immunocompromised (HIV: CD >200)

Question 10

Togavirus precursors

Answer 10

Produces long polypeptide precursor that is cleaved into activated subunits via proteases

Question 11

Buzzwords

Answer 11

Immigrant (can indicated that vaccinations not present)

Descending rash with lymphadenopathy