Picornaviridae overview

Question 1

Picornavirus characteristics

Answer 1

RNA virus (+ sense strand)
Naked (lack viral envelope

Question 2

Transmission

Answer 2

Fecal-oral route- predominantly

Exception (rhinovirus- txmission through respiratory droplets)

Question 3

Replication

Answer 3

Uses host RNA polymerase to translate its RNA to protein (no additional machinery is needed- true for all + sense RNA viruses)

Translated into long poly-protein product; proteases cleave them into active products)

Replicates in the cytoplasm (uses host cell content; host mRNA is analogous to + strand viruses)

Question 4

Family

Answer 4

PERCH:
Enterovirus- Poliovirus, Echovirus, and Coxsackie A and B
Rhinovirus
Hepatitis A

Question 5

Hepatitis A

Answer 5

Causes HSM

Question 6

Enterovirus

Answer 6

1 cause of aseptic (non-bacterial) meningitis

Characteristics: Low glucose, no organisms and elevated proteins
Children are particularly susceptible

Question 7

Rhinovirus

Answer 7

URIs

Question 8

ABCs

Answer 8

A: Hep A
B: Birds- enterovirus
C: Common cold- rhinovirus