Tobacco, Vaping, Medical Marijuana, and Cannabidiol (Wolff) Flashcards
What ingredient found in nearly all cannabis samples has a link with vaping and lung damage?
Vitamin E acetate
Nicotine interferes with maturation of?
Prefrontal cortex
What are the two main cannabinoids found in marijuana?
1) ∆-9-tetrahydrocannabinol (THC)
2) Cannabidiol (CBD)
What is the general MOA of marijuana?
Stimulates endocannabinoid (CB1, CB2) receptors
Endocannabinoids are produced on demand in post-synaptic neurons by stimuli that result in elevations of what ion?
This causes activation of?
Synthesized endocannabinoids then diffuse into the synaptic space, travel in a retrograde manner, and bind to what receptor on presynaptic neuron?
1) Ca2+
2) DAG-lipase
3) CB1R
What are the two major endocannabinoids?
1) anandamide
2) 2-arachidonoylglycerol (2-AG)
The stimulation of presynaptic CB1Rs inhibits?
adenylyl cyclase
Anandamide is broken down by what enzyme found principally in postsynaptic cells?
2-AG is degraded by what enzyme found principally in presynaptic cells?
1) Fatty acid amide hydrolase (FAAH)
2) MAG-lipase (monoacylglycerol lipase)
CB2 receptors are found primarily on?
Immune cells
anandamide and 2-AG have higher affinity for which CB receptor?
CB1
What is Dronabinol?
Orally administered synthetic ∆-9-THC
Effects of dronabinol such as analgesia, appetite enhancement, muscle relaxation and hormonal actions are mediated by which receptor?
CB1
What are the labeled indications for dronabinol?
1) Anorexia in AIDS patient
2) Chemotherapy induced N/V
Cannabis can be recommended for chronic pain, especially for?
Neuropathic pain
How is CBD generally administered?
Orally
