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NMSP Week 6/7 > CNS Stimulant Drugs (Iszard) > Flashcards

CNS Stimulant Drugs (Iszard) Flashcards

1
Q

The stimulants used to treat ADHD are derivatives of?

A

Amphetamine

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2
Q

What are the list of simulants used to treat ADHD?

A

1) Amphetamine
2) Dextroamphetamine
3) Lisdexamfetamine
4) Methylphenidate
5) Dexmethylphenidate

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3
Q

Stimulants enhance neurotransmitter transmission by serving as?

A

Direct & indirect non-catecholamine sympathomimetics

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4
Q

What effect do stimulants have by serving as direct & indirect non-catecholamine sympathomimetics?

A

1) Block presynaptic reuptake
2) Interfere with VMAT (vesicular monoamine transporter)
3) Increase in neurotransmitter release (NE, then DA, then 5-HT)

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5
Q

Which isomers of Amphetamine and Methylphenidate have more CNS activity?

A

D-isomers

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6
Q

What is Methylphenidate’s main activity?

A

Inhibition of dopamine reuptake and inhibition neurotransmitter pre-synaptic reuptake

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7
Q

Does Methylphenidate stimulate the release of neurotransmitters?

A

No

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8
Q

What are rare side effects of stimulants?

A

1) Priapism
2) Seizures
3) Sudden cardiac death
4) Stroke & MI
5) Chemical Leukoderma

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9
Q

How are stimulants prescribed?

A

As controlled substances (1 month supply only, no refills, no samples)

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10
Q

Dextroamphetamine/AMP/Adderall® is given in what form?

What is the duration?

A

1) Tablet

2) 4-6 hours (IR)

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11
Q

Dextroamphetamine Sulfate/ProCentral® is given in what form?

What is the duration?

A

1) Liquid

2) 4-6 hours (IR)

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12
Q

Amphetamine Sulfate/Evekeo® is given in what form?

What is the duration?

A

1) Capsule

2) 4-6 hours (IR)

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13
Q

Dextroamphetamine/Zenzidi® is given in what form?

What is the duration?

A

1) Tablet

2) 4-6 hours (IR)

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14
Q

Dextroamphetamine/Adderall XR® is given in what form?

What is the duration?

A

1) Capsule

2) 8-12 hours (XR)

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15
Q

Dextroamphetamine/Dexedrine® is given in what form?

What is the duration?

A

1) Capsule

2) 8-10 hours (XR)

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16
Q

Amphetamine/Dyanavel XR® is given in what form?

What is the duration?

A

1) Liquid

2) 13 hours (XR)

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17
Q

Lisdexamfetamine/Vyvanse® is given in what form?

What is the duration?

A

1) Capsule

2) 10-12 hours (XR)

18
Q

Amphetamine (Mixed Salts)/Mydayis® is given in what form?

What is the duration?

A

1) Capsule

2) 16 hours (XR)

19
Q

If a patient has trouble swallowing, which Amphetamine-Based Stimulant should be given and why?

A

1) Amphetamine/Dyanavel XR®

2) It’s in liquid form

20
Q

Dexmethylphenidate/Focalin® is given in what form?

What is the duration?

A

1) Tablet

2) 4-6 hours (IR)

21
Q

Methylphenidate/Methylin® is given in what form?

What is the duration?

A

1) Liquid

2) 3-4 hours (IR)

22
Q

Methylphenidate/Ritalin® is given in what form?

What is the duration?

A

1) Tablet

2) 3-4 hours (IR)

23
Q

Methylphenidate/Ritalin-SR® is given in what form?

What is the duration?

A

1) Tablet

2) 4-8 hours (SR)

24
Q

Methamphetamine/Desoxyn® is given in what form?

What is the duration?

A

1) Tablet

2) 4-8 hours (SR)

25
Q

Methylphenidate/Aptensio XR® is given in what form?

What is the duration?

A

1) Capsule

2) 12 hours (ER)

26
Q

Methylphenidate HCl/Concerta® is given in what form?

What is the duration?

A

1) Tablet

2) 10-12 hours (ER)

27
Q

Methylphenidate ER/ Comtempla® XR-ODT is given in what form?

What is the duration?

A

1) Tablet

2) 12 hours (ER)

28
Q

Methylphenidate/Daytrana® is given in what form?

What is the duration?

A

1) Transdermal Patch

2) 10-12 hours (ER)

29
Q

Dexmethylphenidate HCl/ Focalin XR® is given in what form?

What is the duration?

A

1) Capsule

2) 6-10 hours (ER)

30
Q

Methylphenidate HCl/Metadate CD® is given in what form?

What is the duration?

A

1) Capsule

2) 8-10 hours (ER)

31
Q

Methylphenidate HCL ER/Ritalin LA® is given in what form?

What is the duration?

A

1) Capsule

2) 8-10 hours (ER)

32
Q

Methylphenidate HCl/QuilliChew® is given in what form?

What is the duration?

A

1) Chewable Tablet

2) 8 hours (ER)

33
Q

Methylphenidate/Quillivant XR® is given in what form?

What is the duration?

A

1) Liquid

2) 8, 10, 12 hours (ER)

34
Q

If a patient has trouble swallowing, which Methylphenidate-Based Stimulants should be given?

A

1) Methylphenidate/Methylin® Oral Solution

2) Methylphenidate/Quillivant XR®

35
Q

Which Methylphenidate-Based Stimulants can be given in transdermal patch form?

A

Methylphenidate Transdermal/Daytrana®

36
Q

Which Methylphenidate-Based Stimulants can be given in chewable tablet form?

A

Methylphenidate HCl/QuilliChew®

37
Q

What are the list of non-stimulants used to treat ADHD?

A

1) Atomoxetine
2) Guanfacine
3) Clonidine

38
Q

How does the non-stimulant atomoxetine enhance neurotransmitter transmission?

How do the non-stimulants guanfacine/clonidine enhance neurotransmitter transmission?

A

1) Inhibition of NE pre-synaptic reuptake

2) Agonists of CNS α2A adrenergic receptors

39
Q

What is the onset of activity for non-stimulants?

A

1-4+ weeks

40
Q

Atomoxetine is given in what form?

What is the duration?

A

1) Capsule

2) 24 hours (ER)

41
Q

Clonidine and Guanfacine are given in what form?

What is the duration?

A

1) Tablet

2) 12-24 hours (ER)

42
Q

What risk is associated with Clonidine and Guanfacine with abrupt discontinuation?

A

Rebound HTN (both are anti-hypertensives)

NMSP Week 6/7 (18 decks)

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