Tobacco, Vaping, Marijuana, CBD Flashcards
Vaping
Benefits (4) and Risks (3)
Skin, Hair, Fingers, Teeth have better appearance
Sense Smell and Taste improves
Less lung damage (maybe)
Can help stop smoking cigarettes
High levels of youth use (early addiction)
High school students most often use flavors
Believed to not be harmful
Vaping Health Concerns
Physical (1) Pulmonary (2)
E cig explosions
Pneumonitis lung diseases (likely Vit E causes)
DWW increasing deposition of toxins
Nicotine Physiology
Addiction (2) and Adolescent Cognitive Effects (4)
Nicotine causes dopamine release in prefrontal cortex
Adolescents at increased risk due to incomplete prefrontal cortex formation
Impaired neuroplasticity
Decreased cognitive accuracy and impulse control
Decreased memory and attention
Substance abuse and mental health problems
THC Mechanism of Action (2)
Agonist of CB1 receptors inhibits adenylyl cyclase
Hyperpolarization causes decreased GABA release
Fatty Acid Amide Hydrolase Pharmaceutical Interests (4)
Inhibitors of FAAH may have analgesic effects
People with FAAH mutations:
Decreased anxiety
Decreased pain
Heal quickly
Marijuana Regulations
Federal and Missouri (6)
Federal government classifies as Schedule I drug
Missouri has medical marijuana for:
Cancer, Epilepsy, Glaucoma, Chronic pain conditions, PTSD, HIV
Medical Marijuana
Benefits/Uses (9)
Chronic Neuropathic Pain
Nausea/Vomiting
Stimulate appetite
Sleep benefits
Multiple Sclerosis Anxiety Tourette's Parkinson's Alzheimer's
Medical Marijuana Adverse Effects (7)
Judgement/coordination decreased Depression Dizzy Tachycardia Hypotension Hallucinations Adverse effects on intelligence in youth
Medical Marijuana
Ineffective Conditions For Use (7)
Acute pain Tremors Huntington's Glaucoma Schizophrenia Depression Slowing cancer growth
Medical Marijuana Contraindications (3)
Psychosis
Substance abuse disorder
Cardiovascular/Pulmonary disease
Cannabidiol (CBD)
FDA Approved Uses (2) and Potential Uses (8)
Epileptic Conditions:
Dravet syndrome
Lennox-Gastaut Syndrome
Alzheimer's Nausea and Vomiting Pain Fragile X syndrome Skin diseases Cancer CBD Tampons Anxiety/Depression
CBD
Product Legal Status (2) Approved Drug
Hemp Derived CBD is legal for cosmetic use
Illegal for food, dietary supplement or animal feed
Epidiolex
CBD Pharmacokinetics (3) and Mechanism of Action (4)
Extensive first pass liver metabolism CYP metabolized (mostly CYP3A4 and CYP2C19) Lipid soluble and accumulates in adipose
Inverse agonist at CB1 receptors
TRPV1 Agonist
PPAR-gamma Agonist
5-HT 1A Agonist
Synthetic Cannabinoids
Examples (2) and Indication
Dronabinol
Nabilone
Nausea and Vomiting in Chemo patients
