CNS Stimulant Drugs

Question 1

ADHD Drug Legal Considerations

Stimulants and Non-Stimulants

Answer 1

Stimulants:
Controlled Substances
No more than 1 month prescriptions with no refills

Non-Stimulants:
Not Scheduled
Prescriptions up to 1 year

Question 2

Atomoxetine

General Classification, Formulation, Mechanism of Action

Answer 2

Non-Stimulant ADHD drug

Capsule

Decreased presynaptic NE uptake

Question 3

Anti-Hypertensive Non-Stimulant ADHD Drugs

Examples (2), Formulation and Mechanism of Action

Answer 3

Guanfacine
Clonidine

Tablet

CNS alpha-2 agonists

Question 4

Stimulant Drug Common Side Effects (8)

Answer 4

GI Distress
Headache
Decreased Appetite (stunts growth)
Insomnia
Anxiety
Irritability
Psychosis
Elevated BP/HR

Question 5

Stimulant Drug Rare Side Effects (6)

Answer 5

Priapism
Seizure
Sudden Cardiac Death
Stroke
MI
Chemical Leukoderma

Question 6

Immediate Release Amphetamine Based Stimulants

Trade and Generic Names (4) with Formulations

Answer 6

Adderall, Dextroamphetamine, Tablet

ProCentra, Dextroamphetamine Sulfate, Liquid

Evekeo, Amphetamine Sulfate, Capsule

Zenzidi, Dextroamphetamine, Tablet

Question 7

Extended Release Amphetamine Based Stimulants

Trade and Generic Names (5) with Formulations

Answer 7

Adderall XR, Dextroamphetamine, Capsule

Dexedrine, Dextroamphetamine, Capsule

Dyanavel XR, Amphetamine, Liquid

Vyvanse, Lisdexamfetamine, Capsule (prodrug)

Mydayis, Amphetamine, Capsule

Question 8

Adzenys-XR

Generic Drug, Formulation, % of Extended/Immediate

Answer 8

Amphetamine

Oral Dissolving Tablet

50% XR and 50% IR

Question 9

Immediate Release Methylphenidate Based Stimulants

Trade and Generic Names (3) with Formulations

Answer 9

Focalin, Dexmethylphenidate, Tablet

Methylin, Methylphenidate, Liquid

Ritalin, Methylphenidate, Tablet

Question 10

Sustained Release Methylphenidate Based Stimulants

Trade and Generic Names (2) with Formulations

Answer 10

Ritalin-SR, Methylphenidate, Tablet

Desoxyn, Methamphetamine, Tablet

Question 11

Extended Release Methylphenidate Based Stimulants
Trade and Generic Names
Tablet (2) Transdermal Patch (1), Chewable (1) Liquid (1)

Answer 11

Tablet Formulations:
Concerta, Methylphenidate HCl
Comtempla XR-ODT, Methylphenidate ER

Transdermal Patch:
Daytrana, Methylphenidate

Chewable Tablets:
Quillichew, Methylphenidate HCl

Liquid:
Quillivant XR, Methylphenidate

Question 12

Extended Release Methylphenidate Based Stimulants
Trade and Generic Names
Capsule Formulations (4)

Answer 12

“FARM”

Focalin XR, Dexmethylphenidate HCl

Aptensio XR, Methylphenidate

Ritalin LA, Methylphenidate HCl ER

Metadate CD, Methylphenidate HCl

Question 13

Stimulant Medication Mechanisms of Action

Methylphenidate (1), Amphetamines (2), Lisdexamfetamine (3) D Isomers (1)

Answer 13

Methylphenidate: Blocks reuptake of NE, DA and 5-HT

Amphetamines:
Block NE/DA/5-HT reuptake
Increase NE/DA/5-HT release via VMAT

Lisdexamfetamine:
Pro-drug
Inhibits reuptake
Stimulates release

D isomers of MPH/AMP have more CNS activity than L isomers