TNF alpha regulation Flashcards
1
Q
What are the two forms of TNF alpha
A
membrane bound
secreted form
2
Q
How is the secreted form generated
A
cleaved of TNF-a membrane by metalloprotease ADAM17
3
Q
What kind of signalling do the two forms of TNF-a allow for
A
cell-to-cell
autocrine
paracrine
4
Q
Why TNF-a have a short half life
A
first cytokine to be secreted and triggers production of IL-1 and IL-6
5
Q
How is TNF-a bioactivity extended
A
stabilization with heparin
6
Q
How is TNF regulated
A
TNF receptors: TNFR1 and TNFR2
7
Q
TNFR1
A
found on most cells and binds to both soluble and membrane bound TNF
8
Q
TNFR2
A
found only on immune cells
responds only to membrane bound TNF
