IL-1 Regulation Flashcards
1
Q
How is IL-1 expressed
A
membrane IL alpha - for cell-to-cell communication
secreted IL-1 beta - for autocrine, paracrine and endocrine signalling
2
Q
What are IL-alpha and beta stored as
A
precursor molecules
3
Q
bioactivates IL-alpha
A
calpain
4
Q
bioactivates IL-1beta
A
caspase-1
5
Q
Autophagy
A
recycling process where stored pro-IL-1 is loaded into autophagomes
