Properties of TNF alpha

Question 1

effector function

Answer 1

induce programmed cell death (apoptosis) of tumor cells and viral infected cells by activating capase dependent death pathway

Question 2

Is TNF-alpha responsible for inducing sickness behaviour

Answer 2

Yes. activates the CNS at the level of the hypothalamus

Question 3

high doses of TNFaplha can trigger

Answer 3

SIRS and lead to septic shock