TM Rh Group Flashcards
1
Q
Fisher-Race Theory
A
- Rh Blood Group = closely linked loci where crossing over does not occur (CDE)
- besides the D antigen, there are C, c, E, e antigens
2
Q
Describe Rh antigens
A
- polypeptides
- on amphiphilic protein that weaves back and forth through the cell’s membrane
3
Q
Characteristics of Rh antibodies
A
- IgG; clinically significant
- Dosage
- Enzyme-enhanced
4
Q
CDe
A
R¹
5
Q
cDE
A
R²
6
Q
cDe
A
R⁰
7
Q
CDE
A
Rᶻ
8
Q
Cde
A
r’
9
Q
cdE
A
r”
10
Q
cde
A
r
11
Q
CdE
A
rʸ
12
Q
Describe Rh null individuals
A
- no Rh antigens (___/___)
- inherited two copies of amorphic gene OR a suppressor gene = inhibits patient from expressing antigens
- have mild, compensated hemolytic anemia
13
Q
Differentiate genetic weak D vs partial D
A
Genetic weak D:
- most D antigens inside RBC
- difficult for anti-D to access
Partial weak D:
- “mosaic” antigen is missing a piece
- anti-D will not bind to altered epitope during testing = FALSE Rh-
- if patient is given Rh pos blood, patient can form Ab to the piece they lack
14
Q
Most common Rh phenotype in white and black populations ?
A
White: R¹r
Black: R⁰r
15
Q
When is full Rh phenotyping done in blood bank ?
A
- patient history of Rh antibody
- newborns born to Rh neg females (can make Rh antibody against next Rh pos child)
