TM ABO Group Flashcards
ABO and H genes code for..
glycosyltransferases (enzymes)
= adds carbohydrates to type-2 paragloboside chain (Precursor Substance)
What is the ABO type ?
Anti-A = 4+
Anti-B = 4+
A1 cells = 0
B cells = 0
AB
What is the ABO type ?
Anti-A = 0
Anti-B = 0
A1 cells = 4+
B cells = 3+
O
L-fucosyl transferase
- encoded by gene H
- adds L-fucose = H antigens
N-acetyl-D-galactosaminyl
- encoded by gene A
- adds N-acetyl-D-galactosamine
D- galactosyl
- encoded by gene B
- adds D-galactose
T or F: Almost 100% of the population will inherit two H genes
TRUE;
only one H needs to be inherited for L-fucosyl transferase to be produced = adds L-fucose to the PS
the __ antigen allows for other transferases to add sugars and form A and B antigens
H antigen
What kind of molecules are ABO antigens ?
glycoproteins
What are lectins ?
- proteins (found in nature) that bind specific carbs
- act as artificial Abs that bind certain antigens
Ulex europaeus
Anti-H
- seeds have lectin that binds H
Genotype for ABH secretors ?
- SeSe
- Sese
NOTE: only need one “Se” allele
Describe secretors of ABH antigens
- 80% of population (SeSe, Sese)
- make soluble antigens found in plasma, sweat, tears, etc.
ABO group with most amount of H
Type O
NOTE: H antigens have been added to PS
who produces Anti-H ?
- people who did not inherit at least one H allele (only have PS on RBC membrances)
- Bombay blood group
- IgM & naturally occurring