Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IHO Week 1 > TLRs - Innate Immunity > Flashcards

TLRs - Innate Immunity Flashcards

1
Q

What PAMPs and DAMPs does TLR1+ and TLR2 recognize?

A

PAMPs - Triacylated lipoproteins (Pam3CSK4) Peptidoglycans, Lipopolysaccharides
-Also, TLR2 responds to the DAMPs of TLR2+ & TLR6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What PAMPs and DAMPs does TLR2+ and TLR6 recognize?

A

PAMPs - diacylated lipoproteins (FSL-1)
DAMPs - Heat shock proteins (HSP 60, 70, Gp96), High mobility group proteins (HMGB1), Proteoglycans (Version, Hyaluronic Acid fragments)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What PAMPs and DAMPs does TLR3 recognize?

A

PAMPs - dsRNA (poly I:C), tRNA, siRNA

DAMPs - mRNA, tRNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What PAMPs and DAMPs does TLR4 recognize?

A

PAMPs - Lipopolysaccharides (LPS), Paclitaxel
DAMPs - Heat shock proteins (HSP22, 60, 70, 72, Gp96), High mobility group proteins (HMGB1), Proteoglycans (Version, Heparin sulfate, Hyaluronic Acid fragments), Fibronectin, Tenascin-C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What PAMPs and DAMPs does TLR5 recognize?

A

PAMPs - Flagellin

DAMPs - none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What PAMPs and DAMPs does TLR7 recognize?

A

PAMPs - ssRNA Imidazoquinolines (R848), Guanosine analogs (Loxoribine)
DAMPs - ssRNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What PAMPs and DAMPs does TLR8 recognize?

A

PAMPs - ssRNA, Imidazoquinolines (R848)

DAMPs - ssRNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What PAMPs and DAMPs does TLR9 recognize?

A

PAMPs - CpG DNA, CpG ODNs

DAMPs - Chromatin IgG complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What PAMPs and DAMPs does TLR10 recognize?

A

PAMPs - profilin- like proteins

DAMPs - NONE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What TLRs only produce Pro-inflammatory Cytokines (TNF-alpha, IL-6 and IL-12)?

A

TLR1+ & TLR2, TLR2+ & TLR6, TLR5, TLR10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What TLRs produce IFN-beta?

A

TLR3 (dsRNA Poly I:C) and TLR4 (LPS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What TLRs produce IFN-alpha?

A

TLR7, TLR8 (ssRNA) & TLR9 (CpG-DNA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What TLRs produce IFN-beta (via IRF3)?

A

TLR3 (dsRNA Poly I:C) and TLR4 (LPS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What TLRs produce IFN-alpha (via IRF7)?

A

TLR7, TLR8 (ssRNA) & TLR9 (CpG-DNA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What transcription factor does TLR3 and TLR4 turn on?

A

IRF3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What transcription factor does all TLRs turn on (especially TLR4, TLR1+ & TLR2, TLR2 & TLR6, TLR5)?

A

AP-1, p50 and p65

17
Q

What transcription factor does TLR7, TLR8 and TLR9 turn on?

A

IRF7

IHO Week 1 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions