Krafts - Study Questions

Question 1

What tell you whether RBCs are normochromic or hypochromic?

Answer 1

Mean cell hemoglobin concentration (MCHC)

Question 2

What tells you whether a patient’s red cells are microcytic, normocytic or macrocytic?

Answer 2

Mean cell volume (MCV)

Question 3

Anisocytosis refers to:

Answer 3

Variation in red cell size

Question 4

-Massive blood loss, just occurred What is true of the sample of blood?

Answer 4

The hemoglobin will be normal.

Question 5

Which type of anemia involves the attachment of IgG to red cells, which then get eaten up by macrophages in the spleen?

Answer 5

Warm autoimmune hemolytic anemia

Question 6

What labs are consistent with a hemolytic process?

Answer 6

Increased bilirubin
Increased LDH
Decreased Haptoglobin
Increased Reticulocytes

Question 7

What type of anemia involves the attachment of IgM and complement to red cells?

Answer 7

Cold autoimmune hemolytic anemia

Question 8

The red cells in sickle cell disease are more susceptible to hemolysis because:

Answer 8

They possess an abnormal hemoglobin which polymerizes upon deoxygenation

Question 9

28 yr old sister has low hemoglobin.
-Low RBC, Low MCV, High RCW
What is the most likely cause of her anemia?

Answer 9

Iron-deficiency anemia

Question 10

Very poor, limited diet, developed numbness and weakness in extremities. Blood smear showed macrocytic anemia and hypersegmented neutrophils. Which of the following deficiencies is responsible for your grandfather’s symptoms?

Answer 10

Vitamin B12

Question 11

Very poor, limited diet, developed numbness and weakness in extremities. Blood smear showed macrocytic anemia and hyper-segmented neutrophils. Which of the following deficiencies is responsible for your grandfather’s symptoms?

Answer 11

Vitamin B12

Question 12

Worsening fatigue, shortness of breath, few episodes of pneumonia, diffuse petechiae scattered over arms and neck. 
-Hgb low
-MCV normal
-RBC low
-WBC low
-Plt low
What is the most likely cause of anemia?

Answer 12

Aplastic anemia

Question 13

What is a Heinz body?

Answer 13

“eaten out by macrophage bites”

-Denatured globin chains

Question 14

Malignancy, obstetric complications, sepsis and trauma can all cause which of the following findings on blood smear?

Answer 14

Schistocytes (fragmented red cells)

Question 15

Which of the following is true regarding the immunophenotype of normal peripheral blood?

Answer 15

Most lymphocytes are T cells

Question 16

Which of the following blood findings is seen most commonly in infectious mononucleosis?

Answer 16

Reactive lymphocytosis

Question 17

Your patient has elevated neutrophil count. The blood smear shows lots of unusual-looking neutrophils; some have abundant, dark-purple cytoplasmic granules, and other have lots of vacuoles in the cytoplasm. Which disorder is most likely to cause this finding?

Answer 17

E. coli - sepsis

Question 18

-Elevated eosinophil count. Which disorder is the most likely cause?

Answer 18

Drug reaction

Question 19

-Elevated basophil count. What should she be evaluated to see if she has:

Answer 19

Chronic myeloid leukemia