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IHO Week 1 > Micro-organisms Pathologies & Tropisms > Flashcards

Micro-organisms Pathologies & Tropisms Flashcards

1
Q

Pathology of CTFV:

A
  • Saddleback fever pattern

- Travel to mountain West

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2
Q

Pathology of CMV (HHV-5)?

A
  • CMV infectious mononucleosis
  • Heterophile Ab negative
  • Owl’s eyes cells
  • Congenital systemic CMV - deafness
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3
Q

Pathology of HHV-6 & 7?

A
  • Exanthem subitum (aka roseola), rash that develops after a fever resolves
  • Heterophile Ab negative mononucleosis
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4
Q

Pathology of EBV (HHV-4)?

A 
EBV infectious mononucleosis
-Heterophile Ab positive mono
-Burkitt lymphoma: t(8:14)
Hodgkin & non-Hodgkin lymphoma
-Nasopharyngeal lymphom
-X-linked lymphoproliferative disease
-Inherited mutation in SAP adapter
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5
Q

Pathology of Kaposi sarcoma herpes virus (HHV-8)?

A

In immunocompromised only

  • Kaposi sarcoma
  • Primary effusion lymphoma
  • Multifocal Castlemans disease
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6
Q

Pathology of Parvovirus B19?

A

Erythema infectiosum - Fiery red rash on cheek (slapped cheek), transient aplastic crisis in patients with underlying anemia

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7
Q

HTLV-1 and HTLV-2 pathology?

A

Acute T cell lymphoma (ATL)

  • Viral transcription factor Tax drives proliferation; blocks apoptosis
  • HAM/TSP - Inflammation of the spine
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8
Q

HIV-1 and HIV-2 pathology?

A

Acquired immunodeficiency syndrome: depletion of CD4 T cells allows opportunistic infections

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9
Q

Ebola pathology?

A

Hemorrhagic fever

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10
Q

Tropism for Ebola?

A

Macrophages

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11
Q

Tropism for HIV-1, HIV-2?

A

CD4+ T cells (also CD4+ monocytes & macrophages & others)

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12
Q

Tropism for HTLV-1, HTLV-2?

A

T cells (1 - Greater CD4+, 2 - Greater CD8+)

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13
Q

Tropism for Parvovirus B19?

A

Erythroid progenitor cells!

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14
Q

Tropism for Kaposi Sarcoma (KSHV, HHV-8)?

A

In immunocompromised patients only, Kaposi sarcoma, primary effusion lymphoma, multifocal Cattleman’s disease

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15
Q

Tropism for Kaposi Sarcoma (KSHV, HHV-8)?

A

Epithelial Cells, B cells

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16
Q

Tropism for EBV?

A

Acute: epithelial cells of oropharynx (supports lytic life cycle), Latent: B cells

17
Q

Tropism for HHV-6 & 7?

A

CD4+ T cells, PBMNCs, epithelial cells

18
Q

Tropism for Cytomegalovirus?

A

Systemic

-Latent in CD34+ cells (monocyte –> macrophage)

19
Q

Tropism for CTFV?

A

Pro-erythroblasts –> mature RBCs

IHO Week 1 (10 decks)

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