TLRs Flashcards
TLR1:TLR2 heterodimer
Ligands: Lipopeptides, GPI
Microorganisms recognized: Bacteria, parasites
Cellular receptor: Plasma membrane
TLR2:TLR6 heterodimer
Ligands: Lipoteichoic acid, Zymosan
Microorganisms recognized: Gram-positive bacteria, Yeasts
Cellular receptor: Plasma membrane
TLR3
Ligands: Ds viral RNA
Microorganism: West Nile Virus
Cellular receptor: Endosomes
TLR4:TLR4 homodimer
Ligands: Lipopolysaccharide
Microorganism: Gram-negative
Cellular receptor: plasma membrane
TLR5
Ligands: Flagellin
Microorganisms recognized: Motile bacteria having a flagellum
Cellular receptor: Plasma membrane
TLR7
Ligands: ss viral RNA
Microorganisms recognized: HIV
Cellular receptor: endosomes
TLR8
Ligands: ss viral RNA
Microorganisms recognized: influenza
Cellular receptor: endosomes
TLR9
Ligands: unmethylated CpG-rich DNA
Microorganisms recognized: herpes virus
Cellular receptor: endosomes
PRRs
o Specificity- identical mannose receptor buy different microbes can attach
o Receptors are encoded in the germline, limited diversity
o Host cells are not recognized
- important bridge between innate and adaptive immunity
- cause activation and maturation of antigen presenting cell
TLRs that recognize extracellular pathogens
1,2,4,5,6
TLRs that recognize intracellular pathogens
3,7,8,9
TLRs that recognize bacteria
1,2,4,5,6
TLRs that recognize Viruses
3,7,8,9
TLRs that recognize Fungi
2,6