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SFM Biochem/Immuno Quiz 2 > TLRs > Flashcards

TLRs Flashcards

1
Q

TLR1:TLR2 heterodimer

A

Ligands: Lipopeptides, GPI
Microorganisms recognized: Bacteria, parasites
Cellular receptor: Plasma membrane

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2
Q

TLR2:TLR6 heterodimer

A

Ligands: Lipoteichoic acid, Zymosan
Microorganisms recognized: Gram-positive bacteria, Yeasts
Cellular receptor: Plasma membrane

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3
Q

TLR3

A

Ligands: Ds viral RNA
Microorganism: West Nile Virus
Cellular receptor: Endosomes

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4
Q

TLR4:TLR4 homodimer

A

Ligands: Lipopolysaccharide
Microorganism: Gram-negative
Cellular receptor: plasma membrane

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5
Q

TLR5

A

Ligands: Flagellin
Microorganisms recognized: Motile bacteria having a flagellum
Cellular receptor: Plasma membrane

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6
Q

TLR7

A

Ligands: ss viral RNA
Microorganisms recognized: HIV
Cellular receptor: endosomes

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7
Q

TLR8

A

Ligands: ss viral RNA
Microorganisms recognized: influenza
Cellular receptor: endosomes

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8
Q

TLR9

A

Ligands: unmethylated CpG-rich DNA
Microorganisms recognized: herpes virus
Cellular receptor: endosomes

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9
Q

PRRs

A

o Specificity- identical mannose receptor buy different microbes can attach
o Receptors are encoded in the germline, limited diversity
o Host cells are not recognized
- important bridge between innate and adaptive immunity
- cause activation and maturation of antigen presenting cell

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10
Q

TLRs that recognize extracellular pathogens

A

1,2,4,5,6

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11
Q

TLRs that recognize intracellular pathogens

A

3,7,8,9

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12
Q

TLRs that recognize bacteria

A

1,2,4,5,6

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13
Q

TLRs that recognize Viruses

A

3,7,8,9

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14
Q

TLRs that recognize Fungi

A

2,6

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SFM Biochem/Immuno Quiz 2 (12 decks)

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