tissue repair

Question 1

repair comes after what processes?

Answer 1

injury> acute inflammation> necrosis> repair

Question 2

ECM components

Answer 2

collagen, GAGs, elastic fibers, adhesion/regulation

Question 3

cells that will regrow during repair (3 classes)

Answer 3

remnants of injured tissue, vascular endothelium, fibroblasts

Question 4

remnants of injured tissue

Answer 4

regeneration depends on the cell types intrinsic proliferative ability. also provide scaffolding

Question 5

remnants of injured tissue classifications

Answer 5

labile, stable, permanent

Question 6

labile

Answer 6

continuously proliferate, easy repair (epithelial/hematapoetic)

Question 7

stabile

Answer 7

slow growing, but activate in response to GFs (glandular organs, glia, mesenchymal, endothelial, fibroblasts)

Question 8

permanent

Answer 8

little mitotic activity, mainly just scar (heart, brain, skel muscle)

Question 9

normal wound healing steps

Answer 9

homeostasis, inflammation, proliferation, maturation

Question 10

cells in normal wound healing

Answer 10

neutrophils, Mphage, granulation tissue, fibrosis

Question 11

diminished healing causes

Answer 11

maturation (scurvy), metabolic, vascular, genetics (ED)

Question 12

scurvy AA

Answer 12

proline and lysine

Question 13

excessive healing

Answer 13

granulation tissue/ fibrosis (proud flesh, scarring/keloids)

Question 14

PDGF

Answer 14

leukocyte and fibroblast chemoattractant

Question 15

EGF, KGF,

Answer 15

granulation tissue formation and fibroblasts

Question 16

FBF

Answer 16

stimulators of growth factors

Question 17

VEGF

Answer 17

stimulates angiogenesis, increases permeability

Question 18

TGF-B

Answer 18

collagen synthesis,

Question 19

NGF

Answer 19

stimulates nerve growth

Question 20

IL-13

Answer 20

stimulates fibroblasts and collagen synthesis