Tissue Repair Flashcards
Healing
Minimal or no residual defect
Repair
Occurs with tissue loss
Restore of tissue architecture and function after injury
Two ways in which repair occurs
Regeneration-by proliferation of residual cells
Maturation-Stem cells and deposition of connective tissue
Steps in scar formation
Angiogenesis
Granula formation
Remodelling
2 sources in which deposited of connective tissue come from
Migration and proliferation of fibroblasts
Deposition of ecm proteins produced by these cells
Clinical examples of tissue repair and fibrosis
Healing of skin wounds
Fibrosis in injured parenchyma organs
First intention
Involves epithelial layer
Second intention
extensive tissue loss,large wounds ,abscesses,ulceration and ischaemic necrosis