Cell Turnover Flashcards
Growth
Process of increase in size resulting from the synthesis of specific tissue components
Growth
Process of increase in size resulting from the synthesis of specific tissue components
Types of growths and their characteristics
Multiplicative-increase in cell number as result of mitosis
Auxetic-increase in cell size
Accretionary-increase in intercellular rissue components
Combined
Differentiation
Process whereby a cell develops an overt specialized function or morphology that is distinguished from its parent cell
Morphogenesis
Highly complex development of structural shape and form of organs, limbs, facial features
Cell poriferation
Fundamental to :
Development
Maintainance of steady state tissue homeostasis
Replacement of dead or damaged cells
Cell phases
G1-presynthetic phase Restriction point G1/S Checkpoint S-DNA synthesis G2-pre mitotic growth G2/M checkpoint M_mitosis
CDKN1 inhibitiors
p21
p27
p57
Broadly inhibit CDKs
CDKN2 Inhibitiors
p15 b
p17 a
p18 c
p19 d
Selectively effects on 4 and 6
Two essential properties of stem
Self renewal
Asymmetric division
Stem cell locations
Bone marrow Bulge of hair follicle Limbuds of the eye Canals of herrin in the liver Supraventricular zone of the brain