Acute And Chronic Inflammation Flashcards
Acute Inflammation
The initial and often transient series of tissue reaction to injury
Chronic Inflammation
The subsequent and often prolonged tissue reaction following initial response
Acute Inflammation characteristics
Initial, rapid response Within minutes or hours Short duration Exudation of fluid and plasma proteins Emigration of leukocytes(neutrophils)
Chronic Inflammation characteristics
Longer duration Associated with more tissue destruction Proliferation of blood vessels Presence of lymphocytes and macrophages Deposition of connective tissue
Cardinal signs of Inflammation
Redness_Rubor Swelling-Tumor Heat-calor Pain-dolor Loss of function - functio laesa
Sequence of events
Recognition Recruitment of leukocytes and plasma proteins into the tissues Removal of stimulus Regulation of response. Repair
What induces dilation of vessels
Histamine
Exudate
High protein content and may contain white and red cells(cell debris)
Transudate
Low protein content,few cells,low specific gravity
Movement of cells from vessels to site of inflammation (2)
Diapedisis
Transmigration across endothelium
Margination
Crawling and adhesion to endothelium
Serous inflammation
Exudation of cell poor fluid into spaces created by cell injury or body cavities lined
Serous inflammation
Exudation of cell poor fluid into spaces created by cell injury or body cavities lined
Transuade.e.g skin blister from a burn
Fibrinous inflammation
Vascular leaks are large, there’s a local pro-coagulant stimulus
Fibrinogen leaks&Fibrin is formed
Lead to scarring
Purulent (suppurative) inflammation
An exudate-neutrophils liquefied debris of necrotic cells and edema fluid
Ulcers
A local defect of the surface of an organ
