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Pathology > Tissue renewal, regeneration, repair > Flashcards

Tissue renewal, regeneration, repair Flashcards

1
Q

This allows ECM to sketch and recoil

a) Fibrillin
b) Colllagen
c) Elastin
d) Cartilage

A

C

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2
Q

True of collagen?

a) Type 1: predominant in skin & bones
b) has at least 5 types
c) type 2: in basement membrane
d) Enzymatic activity Vitamin E

A

A

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3
Q

Vessel function in adult tissues is:

a) vasculogenesis
b) angiogenesis
c) neovascularisation
d) Both B and C

A

D

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4
Q

True of granulation tissue

a) hallmark of malignancy
b) proliferating blood vessels
c) pink, soft, granular, loose ECM
d) All of the above

A

D

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5
Q

Characterized by wound contraction in which the size of the wound is markedly decreased by the action of myofibroblast

a) healing by first intention
b) healing by second intention
c) fibrosis
d) scar formation

A

B

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6
Q

Same type of tissue replaced the injured one

a) replacement
b) regeneration
c) hyperplasia

A

B

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7
Q

Gives ECM turgor resistance to compression

a) hyaluronan
b) Laminin
c) Fabrillin

A

A

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8
Q

True of collagen

a. Collagen in skin and bone is Type I
b. There are at least 5 types of collagen
c. Type 2 is found in basal membrane
d. Vitamin K is essential in the synthesis of collagen

A

A

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9
Q

Inadequate granulation tissue formation can lead to

a. Contracture
b. Keloid formation
c. Ulceration
d. Proud flesh

A

C

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10
Q

A 36 year old woman undergoes a laparoscopic procedure for her ovarian cysts. A 12 cm scar is left on the abdominal wall. How long before the original tensile strength is restored?

A. One month
B. Three months
C. Six months
D. One year

A

D

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11
Q

The repair of necrosis in the kidney is very different than that in the skin because of

A. different growth factors at the two sites
B. different proliferative capacity of cells
C. different nutritional status of the organs
D. different cell-to-cell communication

A

B

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12
Q

Histologic abnormality of a hypertophic scar in a skin specimen presents as:

A. chronic inflammation
B. granulation tissue
C.excess normal looking dermis
D. dermal collagen thick bands

A

D

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13
Q

A 26 year old male with a long history of drug abuse died after developing progressive pulmonary failure with unproductive cough. The drug market is known to have drugs that were cut (diluted) with contaminants (i.e. Talc & White powder). Upon histological examination,
granulomatous inflammation was found. Theetiologic agent caused this pattern of injury because it was:

A. Infectious
B. Immunogenic
C. Toxic
D. Nondegradable

A

D

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14
Q

In a case of viral myocarditis, the myocardium showed small clusters of lymphocytes on infected myocytes. The major pathologic process in the heart is:

A. acute inflammation
B. chronic inflammation
C. granulation tissue
D. granulomatous inflammation

A

B

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15
Q

Myocardial infiltrates of mononuclear leukocytes are characteristic of:

A. acute viral myocarditis but not chronic viral myocarditis
B. chronic viral myocarditis but not acute viral myocarditis
C. neither chronic viral myocarditis or acute viral myocarditis
D. both chronic viral myocarditis or acute viral myocarditis

A

B

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16
Q

In bacterial killing/degradation, what is the main process?

a. Reactive oxygen species in lysosomes
b. Bactericidal permeability activity
c. Lysozymes
d. Lactoferrin

A

A

17
Q

The cytokines most important in directly producing the systemic inflammation in disease

a. IL-1 and IL-2
b. IL-1 and TNF
c. IL-1 and PDGF
d. TNF and PDGF

A

B

18
Q

Which of the ff. is a “cell-derived inflammatory mediator”?

a. coagulation cascade: fibrin framework
b. bradykinin: pain
c. histamine: vasodilation
d. C3b: phagocytosis

A

C

19
Q

Which of the ff. events is mediated by histamine?

a. endothelial cell contraction
b. endothelial cell detachment
c. leukocytes adhere to endothelium and increase ROS leakage into endothelium
d. increased transcytosis

A

A

20
Q

This factor induces angiogenesis and increases vascular permeability

a. FGF
b. VEGF
c. PDGF
d. TGF-b

A

B

21
Q

This factor induces chemotaxis and endothelial proliferation

a. FGF
b. VEGF
c. PDGF
d. TGF-b

A

A

22
Q

TGF-b is not involved in:

a. neutrophil migration
b. monocyte chemotaxis
c. fibroblast migration
d. fibroblast proliferation

A

A

23
Q

Type of collagen predominant in late, healing wounds

a. I
b. II
c. III
d. IV

A

C

24
Q

Complete regeneration will most likely happen in which of the ff:

a. chronic inflammation w/ high proliferative capacity
b. chronic inflammation w/ low proliferative capacity
c. acute inflammation w/ ECM destruction
d. acute inflammation w/o ECM destruction

A

D

25
Q

Which of the ff is a characteristic of secondary intention?

a. less intense inflammatory reaction
b. wound with extensive tissue loss
c. larger area of wound defect
d. smaller cells of granulation tissue

A

C

26
Q

Granuloma tissue formation is also a feature of other infections aside from Mycobacterium

a. Prion
b. Virus
c. Fungi
d. Ricketssia

A

B

27
Q

Leukocyte adhesion and transmigration is mediated by the following interaction EXCEPT:

a. VCAM  VLA-4
b. P selectin  SLX
c. VCAM-1  MAC 1
d. VCAM-1  L selectin

A

C

28
Q

The nodular structures noted in a cirrhotic liver:

a. Nodules of regulatory hepatocytes
b. Masses of cirrhotic inflammation tissues
c. Fibrotic nodules (e.g. scarring)
d. Foci of granulomatous inflammation

A

C

29
Q

Cell-derived inflammatory mediator:

a. Bradikynin
b. Kallikrein
c. Serotonin
d. Complement

A

C

30
Q

Mediator found in post-inflammatory processes:

a. FGF and EGF
b. FGF and PDGF
c. FGF and VEGF
d. EGF and VEGF

A

B

31
Q

Keloid specimen:

a. chronic inflammation
b. excess granulation tissue
c. excess normal tissue
d. excess collagen bundles in thick bands

A

D

32
Q

Involved in the proliferation of endothelium during wound healing

a. TGF-β; VEGF
b. TGF-β; FGF
c. VEGF; PDGF
d. FGF; VEGF

A

D

33
Q

The cytokines that are most important in the systemic signs and symptoms of chronic inflammatory reaction.

a. IL-1 and IL-2
b. IL-1 and TNF
c. IL-2 and PDGF
d. TNF and PDGF

A

B

34
Q

Restitution/resolution happens during the following, EXCEPT:

a. in chronic inflammation
b. only when inciting agent is removed
c. even if cell debris remain
d. high proliferative capacity

A

C

35
Q

Type of collagen used for healing:

a. Type I
b. Type II
c. Type III
d. Type IV

A

C

Pathology (6 decks)

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