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Pathology > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q

The malignant counterpart of ovarian dermoid cyst is termed as:

a) Dermatofibroma
b) Cystadenoma
c) choriocarcinoma
d) immature teratoma

A

D

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2
Q

The single most common abnormality in dominant oncogene of tumors in humans in the point mutation in:

a) RAS
b) RET
c) cylin – DI

A

A

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3
Q

In adenoma carcinoma model of colon carcinogenesis, the initial event is:

a) Activation of APC
b) Activation of RAS
c) Loss of tumor suppressor gene on chromosome 18q
d) loss of p53

A

A

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4
Q

Dysregulation in MYC gene occurs in

a) CML
b) Neuroblastoma
c) Burkette

A

C

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5
Q

Reduplication of DNA sequences produced by several changes in the proto-oncogene are exemplified by

a) BCR 2/neu in breast cancer
b) BCR – ABL in chronic myelogenous leukemia
c) Rb in retinoblastoma
d) Bcl2 in follicular lymphoma

A

A

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6
Q

Example of apoptosis gene

a) ras
b) n-myc
c) rb
d) bcl – 2

A

D

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7
Q

Molecular policeman:

a) APC
b) p 53
c) rb gen

A

B

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8
Q

Mesothelioma is strongly associated with exposure to:

a) Arsenic
b) Asbestos
c) Cadmium
d) Vinyl chloride

A

B

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9
Q

What is true of HPV in cervical carcinogenesis

a) Associated with type 16 & 18
b) Genome is non-integrated
c) Aggregation is non-clonal
d) Associated with host proto-oncogene

A

A

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10
Q

A neoplasm associated with Helicobacter pylori

a) Gastric cancer
b) Nasopharyngeal cancer
c) Leukemia
d) Burkitt lymphoma

A

A

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11
Q

What is the most common paraneoplastic condition?

a) Polycythemia
b) Hypercalcemia
c) Hypoglycemia
d) Myesthenia

A

B

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12
Q

True of cancer cachexia

a) loss of ion muscle only
b) caused by nutritional demands of tumor
c) patient’s metabolic rate is reduced
d) effects of cytokines

A

D

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13
Q

Which of the following factors favors the formation and vessels in a tumor?

a) vasculostatin
b) angiostatin
c) thromboxanes
d) beta fibroblast growth factor

A

D

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14
Q

Flow cytometry is helpful in:

a) characterization of leukemia
b) intraoperative consultation
c) diagnosis of cervical cancer
d) Her2/neu protein detection

A

A

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15
Q

A Fetoprotein is a marker for carcinoma of what organ?

a) thyroid
b) liver
c) pancreas
d) stomach

A

B

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16
Q

Tumors will not elicit an immune response

a) no production of tumor antigens
b) activation of immune system by chemical carcinogens
c) decreased cytotoxic T- cell
d) overexpression of HLA Type I

A

A

17
Q

Which one is a benign neoplasm?

a. Hepatoma
b. Lymphoma
c. Melanoma
d. Adenoma

A

D

18
Q

Which of the following conditions predisposes to neoplastic formation?

A. Physiologic hypertrophy
B. Physiologic hyperplasia
C. Metaplasia
D. Atrophy

A

C

19
Q

Which is not an oncogene?

A. Human Papilloma Virus
B. Hepatitis B Virus
C. Herpes Virus
D. Epstein Barr Virus

A

C

20
Q

Which is not a malignant tumor?

A. Lymphoma
B. Melanoma
C. Leiomyosarcoma
D. Hamartoma

A

D

21
Q

Leading cause of cancer in men:

A. Skin Cancer
B. Prostate Cancer
C. Lung Cancer
D. Testicular Cancer

A

B

22
Q

Characteristic of benign tumor

A. Invasive
B. Cohesive
C. Immortal
D. Escape from regulatory control

A

B

23
Q

Identify which gene is involved. A 45 year old woman has a 2cm mass on her right breast. She has it taken out….pathologist’s results show ductal carcinoma—grade 3. As a resident, they ask you to conduct immunochemistry to
verify.

A. ki-RAS
B. c-src
C. BCR/abl gene
D. c-myc

A

D

24
Q

All of the following are tumor-suppressor genes except:

A. p53
B. APC
C. Bcl-2
D. NF-1

A

C

25
Q

Sarcoma is malignant neoplasm of:

a. endothelial cell
b. epithelial cell
c. mesenchymal cell
d. NOTA

A

A

26
Q

A polyp:

a. Is not a neoplasm
b. Always has a stalk
c. Maybe benign or malignant
d. Regresses spontaneously

A

B

27
Q

High incidence of malignancy in both males and females:

a. lung
b. liver
c. spleen
d. GI

A

A

28
Q

In a specimen showing pericarditis, the irregular masses of deeply acidophilic acellular material at the surface of the pericardium are:

a. fibrinous exudate
b. necrotic debris
c. thrombotic material
d. granulomatous inflammation

A

A

29
Q

Dysplasia

a. Always proceeds to malignancy
b. Is irreversible
c. Is disorganized growth of epithelium

A

C

30
Q

Which characteristic is the hallmark of malignancy?

a. Mitotically active cells
b. Giant cells
c. Paraneoplastic syndrome
d. Lymphatic spread

A

D

31
Q

The Epstein-Barr virus is implicated in which tumor?

a. cervical cancer
b. hepatocellular carcinoma
c. Burkitt lymphoma
d. lung cancer

A

C

32
Q

Most common paraneoplastic syndrome:

a. Cushing’s syndrome
b. Hypercalcemia
c. Myasthenia gravis
d. Polycythemia

A

B

33
Q

The amount of differntiation and/or mitotic activity of a tumor is the basis for:

a. tumor nomenclature
b. tumor spread
c. tumor stage
d. tumor grade

A

D

34
Q

What is the significance of immunohistochemistry?

a. cancer screening
b. identify mitoses
c. quantify DNA
d. categorize lymphoma

A

D

35
Q

Development of hereditary nonpolyposis cancer syndrome requests:

a. Evasion of apoptosis
b. Loss of tumor suppressing gene
c. defect in DNA repair
d. Gene amplification

A

C

36
Q

The most common abnormality of dominant oncogene:

a. Ras mutation
b. Myc overexpression
c. Rb deletion
d. p53 loss

A

A

37
Q

A benign tumor arising from the lymph vessels is properly termed as:

a) Lipoma
b) Lymphoma
c) Lymphangioma
d) Lymphangiosarcoma

A

D

Pathology (6 decks)

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